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The silence of MUC2 mRNA induced by promoter hypermethylation associated with HBV in Hepatocellular Carcinoma

BACKGROUND: To evaluate the promoter methylation status of MUC2 gene and mRNA expression in patients with hepatocellular carcinoma. METHODS: We analyzed MUC2 methylation by MSP, and MUC2 mRNA by real-time PCR in 74 HCC. RESULTS: MUC2 mRNA were lower in HCC tissues (Mean (-ΔCt) = −4.70) than that in...

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Detalles Bibliográficos
Autores principales:	Ling, Yang, Zhu, Jing, Gao, Lu, Liu, Yongping, Zhu, Changtai, Li, Rong, Wei, Lixin, Zhang, Changsong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583682/ https://www.ncbi.nlm.nih.gov/pubmed/23347460 http://dx.doi.org/10.1186/1471-2350-14-14

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