Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations

Hedgehog (HH) pathway Smoothened (Smo) inhibitors are active against Gorlin syndrome-associated basal cell carcinoma (BCC) and medulloblastoma where Patched (Ptch) mutations occur. We interrogated 705 epithelial cancer cell lines for growth response to the Smo inhibitor cyclopamine and for expressed...

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Detalles Bibliográficos
Autores principales: GALIMBERTI, FABRIZIO, BUSCH, ALEXANDER M., CHINYENGETERE, FADZAI, MA, TIAN, SEKULA, DAVID, MEMOLI, VINCENT A., DRAGNEV, KONSTANTIN H., LIU, FANG, JOHNSON, KEVIN C., GUO, YONGLI, FREEMANTLE, SARAH J., ANDREW, ANGELINE S., GRENINGER, PATRICIA, ROBBINS, DAVID J., SETTLEMAN, JEFF, BENES, CYRIL, DMITROVSKY, ETHAN
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583816/
https://www.ncbi.nlm.nih.gov/pubmed/22923130
http://dx.doi.org/10.3892/ijo.2012.1599

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