The role of manganese superoxide dismutase in skin aging

The free radical theory of aging postulates that the production of mitochondrial reactive oxygen species is the major determinant of aging and lifespan. The skin represents an excellent and accessible model organ to study aging that is characterized by atrophy, wrinkle formation, reduced tensile str...

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Autores principales: Treiber, Nicolai, Maity, Pallab, Singh, Karmveer, Ferchiu, Florentina, Wlaschek, Meinhard, Scharffetter-Kochanek, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583882/
https://www.ncbi.nlm.nih.gov/pubmed/23467724
http://dx.doi.org/10.4161/derm.21819
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author Treiber, Nicolai
Maity, Pallab
Singh, Karmveer
Ferchiu, Florentina
Wlaschek, Meinhard
Scharffetter-Kochanek, Karin
author_facet Treiber, Nicolai
Maity, Pallab
Singh, Karmveer
Ferchiu, Florentina
Wlaschek, Meinhard
Scharffetter-Kochanek, Karin
author_sort Treiber, Nicolai
collection PubMed
description The free radical theory of aging postulates that the production of mitochondrial reactive oxygen species is the major determinant of aging and lifespan. The skin represents an excellent and accessible model organ to study aging that is characterized by atrophy, wrinkle formation, reduced tensile strength and impaired wound healing. Oxidative stress as a consequence of an imbalance in prooxidants and antioxidants with increased ROS concentrations has been demonstrated in the aged skin in vitro and in vivo, suggesting the important role of the antioxidant balance. Here we will summarize recent data on the role of the mitochondrial superoxide dismutase 2 in skin aging.
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spelling pubmed-35838822013-03-06 The role of manganese superoxide dismutase in skin aging Treiber, Nicolai Maity, Pallab Singh, Karmveer Ferchiu, Florentina Wlaschek, Meinhard Scharffetter-Kochanek, Karin Dermatoendocrinol Review The free radical theory of aging postulates that the production of mitochondrial reactive oxygen species is the major determinant of aging and lifespan. The skin represents an excellent and accessible model organ to study aging that is characterized by atrophy, wrinkle formation, reduced tensile strength and impaired wound healing. Oxidative stress as a consequence of an imbalance in prooxidants and antioxidants with increased ROS concentrations has been demonstrated in the aged skin in vitro and in vivo, suggesting the important role of the antioxidant balance. Here we will summarize recent data on the role of the mitochondrial superoxide dismutase 2 in skin aging. Landes Bioscience 2012-07-01 /pmc/articles/PMC3583882/ /pubmed/23467724 http://dx.doi.org/10.4161/derm.21819 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Treiber, Nicolai
Maity, Pallab
Singh, Karmveer
Ferchiu, Florentina
Wlaschek, Meinhard
Scharffetter-Kochanek, Karin
The role of manganese superoxide dismutase in skin aging
title The role of manganese superoxide dismutase in skin aging
title_full The role of manganese superoxide dismutase in skin aging
title_fullStr The role of manganese superoxide dismutase in skin aging
title_full_unstemmed The role of manganese superoxide dismutase in skin aging
title_short The role of manganese superoxide dismutase in skin aging
title_sort role of manganese superoxide dismutase in skin aging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583882/
https://www.ncbi.nlm.nih.gov/pubmed/23467724
http://dx.doi.org/10.4161/derm.21819
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