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Hyaluronic acid: A key molecule in skin aging

Skin aging is a multifactorial process consisting of two distinct and independent mechanisms: intrinsic and extrinsic aging. Youthful skin retains its turgor, resilience and pliability, among others, due to its high content of water. Daily external injury, in addition to the normal process of aging,...

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Detalles Bibliográficos
Autores principales: Papakonstantinou, Eleni, Roth, Michael, Karakiulakis, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583886/
https://www.ncbi.nlm.nih.gov/pubmed/23467280
http://dx.doi.org/10.4161/derm.21923
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author Papakonstantinou, Eleni
Roth, Michael
Karakiulakis, George
author_facet Papakonstantinou, Eleni
Roth, Michael
Karakiulakis, George
author_sort Papakonstantinou, Eleni
collection PubMed
description Skin aging is a multifactorial process consisting of two distinct and independent mechanisms: intrinsic and extrinsic aging. Youthful skin retains its turgor, resilience and pliability, among others, due to its high content of water. Daily external injury, in addition to the normal process of aging, causes loss of moisture. The key molecule involved in skin moisture is hyaluronic acid (HA) that has unique capacity in retaining water. There are multiple sites for the control of HA synthesis, deposition, cell and protein association and degradation, reflecting the complexity of HA metabolism. The enzymes that synthesize or catabolize HA and HA receptors responsible for many of the functions of HA are all multigene families with distinct patterns of tissue expression. Understanding the metabolism of HA in the different layers of the skin and the interactions of HA with other skin components will facilitate the ability to modulate skin moisture in a rational manner.
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spelling pubmed-35838862013-03-06 Hyaluronic acid: A key molecule in skin aging Papakonstantinou, Eleni Roth, Michael Karakiulakis, George Dermatoendocrinol Review Skin aging is a multifactorial process consisting of two distinct and independent mechanisms: intrinsic and extrinsic aging. Youthful skin retains its turgor, resilience and pliability, among others, due to its high content of water. Daily external injury, in addition to the normal process of aging, causes loss of moisture. The key molecule involved in skin moisture is hyaluronic acid (HA) that has unique capacity in retaining water. There are multiple sites for the control of HA synthesis, deposition, cell and protein association and degradation, reflecting the complexity of HA metabolism. The enzymes that synthesize or catabolize HA and HA receptors responsible for many of the functions of HA are all multigene families with distinct patterns of tissue expression. Understanding the metabolism of HA in the different layers of the skin and the interactions of HA with other skin components will facilitate the ability to modulate skin moisture in a rational manner. Landes Bioscience 2012-07-01 /pmc/articles/PMC3583886/ /pubmed/23467280 http://dx.doi.org/10.4161/derm.21923 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Papakonstantinou, Eleni
Roth, Michael
Karakiulakis, George
Hyaluronic acid: A key molecule in skin aging
title Hyaluronic acid: A key molecule in skin aging
title_full Hyaluronic acid: A key molecule in skin aging
title_fullStr Hyaluronic acid: A key molecule in skin aging
title_full_unstemmed Hyaluronic acid: A key molecule in skin aging
title_short Hyaluronic acid: A key molecule in skin aging
title_sort hyaluronic acid: a key molecule in skin aging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583886/
https://www.ncbi.nlm.nih.gov/pubmed/23467280
http://dx.doi.org/10.4161/derm.21923
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