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Advanced glycation end products: Key players in skin aging?

Aging is the progressive accumulation of damage to an organism over time leading to disease and death. Aging research has been very intensive in the last years aiming at characterizing the pathophysiology of aging and finding possibilities to fight age-related diseases. Various theories of aging hav...

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Detalles Bibliográficos
Autores principales: Gkogkolou, Paraskevi, Böhm, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583887/
https://www.ncbi.nlm.nih.gov/pubmed/23467327
http://dx.doi.org/10.4161/derm.22028
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author Gkogkolou, Paraskevi
Böhm, Markus
author_facet Gkogkolou, Paraskevi
Böhm, Markus
author_sort Gkogkolou, Paraskevi
collection PubMed
description Aging is the progressive accumulation of damage to an organism over time leading to disease and death. Aging research has been very intensive in the last years aiming at characterizing the pathophysiology of aging and finding possibilities to fight age-related diseases. Various theories of aging have been proposed. In the last years advanced glycation end products (AGEs) have received particular attention in this context. AGEs are formed in high amounts in diabetes but also in the physiological organism during aging. They have been etiologically implicated in numerous diabetes- and age-related diseases. Strategies inhibiting AGE accumulation and signaling seem to possess a therapeutic potential in these pathologies. However, still little is known on the precise role of AGEs during skin aging. In this review the existing literature on AGEs and skin aging will be reviewed. In addition, existing and potential anti-AGE strategies that may be beneficial on skin aging will be discussed.
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spelling pubmed-35838872013-03-06 Advanced glycation end products: Key players in skin aging? Gkogkolou, Paraskevi Böhm, Markus Dermatoendocrinol Review Aging is the progressive accumulation of damage to an organism over time leading to disease and death. Aging research has been very intensive in the last years aiming at characterizing the pathophysiology of aging and finding possibilities to fight age-related diseases. Various theories of aging have been proposed. In the last years advanced glycation end products (AGEs) have received particular attention in this context. AGEs are formed in high amounts in diabetes but also in the physiological organism during aging. They have been etiologically implicated in numerous diabetes- and age-related diseases. Strategies inhibiting AGE accumulation and signaling seem to possess a therapeutic potential in these pathologies. However, still little is known on the precise role of AGEs during skin aging. In this review the existing literature on AGEs and skin aging will be reviewed. In addition, existing and potential anti-AGE strategies that may be beneficial on skin aging will be discussed. Landes Bioscience 2012-07-01 /pmc/articles/PMC3583887/ /pubmed/23467327 http://dx.doi.org/10.4161/derm.22028 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Gkogkolou, Paraskevi
Böhm, Markus
Advanced glycation end products: Key players in skin aging?
title Advanced glycation end products: Key players in skin aging?
title_full Advanced glycation end products: Key players in skin aging?
title_fullStr Advanced glycation end products: Key players in skin aging?
title_full_unstemmed Advanced glycation end products: Key players in skin aging?
title_short Advanced glycation end products: Key players in skin aging?
title_sort advanced glycation end products: key players in skin aging?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583887/
https://www.ncbi.nlm.nih.gov/pubmed/23467327
http://dx.doi.org/10.4161/derm.22028
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