Extrinsic aging: UV-mediated skin carcinogenesis

Age-associated skin lesions linked to UV radiation (UVR) include actinic keratosis, non-melanoma skin cancer—such as basal cell carcinoma and squamous cell carcinoma—lentigo senilis and lentigo maligna. Their incidence is increasing worldwide, mainly due to exaggerated UV exposure and to an aging population. Early diagnosis and therapy of pre-malignant cutaneous lesions is crucial for the secondary prophylaxis of invasive and highly aggressive skin cancers. Combined efforts to increase public awareness, patient education about self-examination, prophylactic modalities, such as consistent and sufficient UV protection, and rigorous follow-up of high-risk groups are of highest importance.