A delicate balance: CD73-generated adenosine limits the severity of graft vs. host disease but also constrains the allogeneic graft vs. tumor effect

The utility of allogeneic stem cell transplantation for treating hematologic malignancies is enhanced by the graft vs. tumor (GvT) effect, but limited by graft vs. host disease (GvHD). Studies involving the inhibition of CD73 by genetic or pharmacologic means suggest that the levels of CD73-generate...

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Detalles Bibliográficos
Autores principales: Thompson, Linda F., Tsukamoto, Hiroki, Chernogorova, Petya, Zeiser, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583907/
https://www.ncbi.nlm.nih.gov/pubmed/23482243
http://dx.doi.org/10.4161/onci.22107
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author Thompson, Linda F.
Tsukamoto, Hiroki
Chernogorova, Petya
Zeiser, Robert
author_facet Thompson, Linda F.
Tsukamoto, Hiroki
Chernogorova, Petya
Zeiser, Robert
author_sort Thompson, Linda F.
collection PubMed
description The utility of allogeneic stem cell transplantation for treating hematologic malignancies is enhanced by the graft vs. tumor (GvT) effect, but limited by graft vs. host disease (GvHD). Studies involving the inhibition of CD73 by genetic or pharmacologic means suggest that the levels of CD73-generated adenosine may be manipulated to control GvHD, while maintaining the GvT effect.
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spelling pubmed-35839072013-03-11 A delicate balance: CD73-generated adenosine limits the severity of graft vs. host disease but also constrains the allogeneic graft vs. tumor effect Thompson, Linda F. Tsukamoto, Hiroki Chernogorova, Petya Zeiser, Robert Oncoimmunology Author's View The utility of allogeneic stem cell transplantation for treating hematologic malignancies is enhanced by the graft vs. tumor (GvT) effect, but limited by graft vs. host disease (GvHD). Studies involving the inhibition of CD73 by genetic or pharmacologic means suggest that the levels of CD73-generated adenosine may be manipulated to control GvHD, while maintaining the GvT effect. Landes Bioscience 2013-01-01 /pmc/articles/PMC3583907/ /pubmed/23482243 http://dx.doi.org/10.4161/onci.22107 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Thompson, Linda F.
Tsukamoto, Hiroki
Chernogorova, Petya
Zeiser, Robert
A delicate balance: CD73-generated adenosine limits the severity of graft vs. host disease but also constrains the allogeneic graft vs. tumor effect
title A delicate balance: CD73-generated adenosine limits the severity of graft vs. host disease but also constrains the allogeneic graft vs. tumor effect
title_full A delicate balance: CD73-generated adenosine limits the severity of graft vs. host disease but also constrains the allogeneic graft vs. tumor effect
title_fullStr A delicate balance: CD73-generated adenosine limits the severity of graft vs. host disease but also constrains the allogeneic graft vs. tumor effect
title_full_unstemmed A delicate balance: CD73-generated adenosine limits the severity of graft vs. host disease but also constrains the allogeneic graft vs. tumor effect
title_short A delicate balance: CD73-generated adenosine limits the severity of graft vs. host disease but also constrains the allogeneic graft vs. tumor effect
title_sort delicate balance: cd73-generated adenosine limits the severity of graft vs. host disease but also constrains the allogeneic graft vs. tumor effect
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583907/
https://www.ncbi.nlm.nih.gov/pubmed/23482243
http://dx.doi.org/10.4161/onci.22107
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