NKG2D ligands link oncogenic RAS to innate immunity

RAS is constitutively active in multiple types of tumor cells. We have recently demonstrated that H-RASV12 enhances the translation of ligands for the activating immune receptor NKG2D, hence rendering cells more susceptible to natural killer (NK) cell-mediated lysis. This effect depends on MAPK and...

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Detalles Bibliográficos
Autores principales: Ho, Samantha S.W., Gasser, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583909/
https://www.ncbi.nlm.nih.gov/pubmed/23482418
http://dx.doi.org/10.4161/onci.22244
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author Ho, Samantha S.W.
Gasser, Stephan
author_facet Ho, Samantha S.W.
Gasser, Stephan
author_sort Ho, Samantha S.W.
collection PubMed
description RAS is constitutively active in multiple types of tumor cells. We have recently demonstrated that H-RASV12 enhances the translation of ligands for the activating immune receptor NKG2D, hence rendering cells more susceptible to natural killer (NK) cell-mediated lysis. This effect depends on MAPK and PI3K signaling, but not on the DNA damage response.
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spelling pubmed-35839092013-03-11 NKG2D ligands link oncogenic RAS to innate immunity Ho, Samantha S.W. Gasser, Stephan Oncoimmunology Author's View RAS is constitutively active in multiple types of tumor cells. We have recently demonstrated that H-RASV12 enhances the translation of ligands for the activating immune receptor NKG2D, hence rendering cells more susceptible to natural killer (NK) cell-mediated lysis. This effect depends on MAPK and PI3K signaling, but not on the DNA damage response. Landes Bioscience 2013-01-01 /pmc/articles/PMC3583909/ /pubmed/23482418 http://dx.doi.org/10.4161/onci.22244 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Ho, Samantha S.W.
Gasser, Stephan
NKG2D ligands link oncogenic RAS to innate immunity
title NKG2D ligands link oncogenic RAS to innate immunity
title_full NKG2D ligands link oncogenic RAS to innate immunity
title_fullStr NKG2D ligands link oncogenic RAS to innate immunity
title_full_unstemmed NKG2D ligands link oncogenic RAS to innate immunity
title_short NKG2D ligands link oncogenic RAS to innate immunity
title_sort nkg2d ligands link oncogenic ras to innate immunity
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583909/
https://www.ncbi.nlm.nih.gov/pubmed/23482418
http://dx.doi.org/10.4161/onci.22244
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