Metastamir-mediated immune evasion: miR-10b downregulates the stress-induced molecule MICB, hence avoid recognition by NKG2D receptor

Metastases are responsible for more than 90% of cancer-related deaths. We have recently reported that miR-10b inhibits the expression of MICB, a stress-induced ligand of the activating natural killer (NK)-cell receptor NKG2D. Here, we discuss our findings, which link metastasis formation to immune e...

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Detalles Bibliográficos
Autores principales: Tsukerman, Pinchas, Enk, Jonatan, Mandelboim, Ofer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583910/
https://www.ncbi.nlm.nih.gov/pubmed/23479551
http://dx.doi.org/10.4161/onci.22245
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author Tsukerman, Pinchas
Enk, Jonatan
Mandelboim, Ofer
author_facet Tsukerman, Pinchas
Enk, Jonatan
Mandelboim, Ofer
author_sort Tsukerman, Pinchas
collection PubMed
description Metastases are responsible for more than 90% of cancer-related deaths. We have recently reported that miR-10b inhibits the expression of MICB, a stress-induced ligand of the activating natural killer (NK)-cell receptor NKG2D. Here, we discuss our findings, which link metastasis formation to immune evasion.
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spelling pubmed-35839102013-03-11 Metastamir-mediated immune evasion: miR-10b downregulates the stress-induced molecule MICB, hence avoid recognition by NKG2D receptor Tsukerman, Pinchas Enk, Jonatan Mandelboim, Ofer Oncoimmunology Author's View Metastases are responsible for more than 90% of cancer-related deaths. We have recently reported that miR-10b inhibits the expression of MICB, a stress-induced ligand of the activating natural killer (NK)-cell receptor NKG2D. Here, we discuss our findings, which link metastasis formation to immune evasion. Landes Bioscience 2013-01-01 /pmc/articles/PMC3583910/ /pubmed/23479551 http://dx.doi.org/10.4161/onci.22245 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Tsukerman, Pinchas
Enk, Jonatan
Mandelboim, Ofer
Metastamir-mediated immune evasion: miR-10b downregulates the stress-induced molecule MICB, hence avoid recognition by NKG2D receptor
title Metastamir-mediated immune evasion: miR-10b downregulates the stress-induced molecule MICB, hence avoid recognition by NKG2D receptor
title_full Metastamir-mediated immune evasion: miR-10b downregulates the stress-induced molecule MICB, hence avoid recognition by NKG2D receptor
title_fullStr Metastamir-mediated immune evasion: miR-10b downregulates the stress-induced molecule MICB, hence avoid recognition by NKG2D receptor
title_full_unstemmed Metastamir-mediated immune evasion: miR-10b downregulates the stress-induced molecule MICB, hence avoid recognition by NKG2D receptor
title_short Metastamir-mediated immune evasion: miR-10b downregulates the stress-induced molecule MICB, hence avoid recognition by NKG2D receptor
title_sort metastamir-mediated immune evasion: mir-10b downregulates the stress-induced molecule micb, hence avoid recognition by nkg2d receptor
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583910/
https://www.ncbi.nlm.nih.gov/pubmed/23479551
http://dx.doi.org/10.4161/onci.22245
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AT mandelboimofer metastamirmediatedimmuneevasionmir10bdownregulatesthestressinducedmoleculemicbhenceavoidrecognitionbynkg2dreceptor

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