Plasmacytoid dendritic cells deficient in IFNα production promote the amplification of FOXP3(+) regulatory T cells and are associated with poor prognosis in breast cancer patients

The accumulation of plasmacytoid dendritic cells (pDCs) within breast carcinoma lesions is associated with a poor clinical outcome. We demonstrated that the deleterious impact of tumor-associated pDCs (TApDCs) is due to their impaired capacity to produce Type I interferon, which in turn potentiates...

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Autores principales: Sisirak, Vanja, Faget, Julien, Vey, Nelly, Blay, Jean-Yves, Ménétrier-Caux, Christine, Caux, Christophe, Bendriss-Vermare, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583914/
https://www.ncbi.nlm.nih.gov/pubmed/23482834
http://dx.doi.org/10.4161/onci.22338
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author Sisirak, Vanja
Faget, Julien
Vey, Nelly
Blay, Jean-Yves
Ménétrier-Caux, Christine
Caux, Christophe
Bendriss-Vermare, Nathalie
author_facet Sisirak, Vanja
Faget, Julien
Vey, Nelly
Blay, Jean-Yves
Ménétrier-Caux, Christine
Caux, Christophe
Bendriss-Vermare, Nathalie
author_sort Sisirak, Vanja
collection PubMed
description The accumulation of plasmacytoid dendritic cells (pDCs) within breast carcinoma lesions is associated with a poor clinical outcome. We demonstrated that the deleterious impact of tumor-associated pDCs (TApDCs) is due to their impaired capacity to produce Type I interferon, which in turn potentiates their ability to sustain the proliferation of immunosuppressive regulatory T cells.
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spelling pubmed-35839142013-03-11 Plasmacytoid dendritic cells deficient in IFNα production promote the amplification of FOXP3(+) regulatory T cells and are associated with poor prognosis in breast cancer patients Sisirak, Vanja Faget, Julien Vey, Nelly Blay, Jean-Yves Ménétrier-Caux, Christine Caux, Christophe Bendriss-Vermare, Nathalie Oncoimmunology Author's View The accumulation of plasmacytoid dendritic cells (pDCs) within breast carcinoma lesions is associated with a poor clinical outcome. We demonstrated that the deleterious impact of tumor-associated pDCs (TApDCs) is due to their impaired capacity to produce Type I interferon, which in turn potentiates their ability to sustain the proliferation of immunosuppressive regulatory T cells. Landes Bioscience 2013-01-01 /pmc/articles/PMC3583914/ /pubmed/23482834 http://dx.doi.org/10.4161/onci.22338 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Sisirak, Vanja
Faget, Julien
Vey, Nelly
Blay, Jean-Yves
Ménétrier-Caux, Christine
Caux, Christophe
Bendriss-Vermare, Nathalie
Plasmacytoid dendritic cells deficient in IFNα production promote the amplification of FOXP3(+) regulatory T cells and are associated with poor prognosis in breast cancer patients
title Plasmacytoid dendritic cells deficient in IFNα production promote the amplification of FOXP3(+) regulatory T cells and are associated with poor prognosis in breast cancer patients
title_full Plasmacytoid dendritic cells deficient in IFNα production promote the amplification of FOXP3(+) regulatory T cells and are associated with poor prognosis in breast cancer patients
title_fullStr Plasmacytoid dendritic cells deficient in IFNα production promote the amplification of FOXP3(+) regulatory T cells and are associated with poor prognosis in breast cancer patients
title_full_unstemmed Plasmacytoid dendritic cells deficient in IFNα production promote the amplification of FOXP3(+) regulatory T cells and are associated with poor prognosis in breast cancer patients
title_short Plasmacytoid dendritic cells deficient in IFNα production promote the amplification of FOXP3(+) regulatory T cells and are associated with poor prognosis in breast cancer patients
title_sort plasmacytoid dendritic cells deficient in ifnα production promote the amplification of foxp3(+) regulatory t cells and are associated with poor prognosis in breast cancer patients
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583914/
https://www.ncbi.nlm.nih.gov/pubmed/23482834
http://dx.doi.org/10.4161/onci.22338
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