Plasmacytoid dendritic cells deficient in IFNα production promote the amplification of FOXP3(+) regulatory T cells and are associated with poor prognosis in breast cancer patients

The accumulation of plasmacytoid dendritic cells (pDCs) within breast carcinoma lesions is associated with a poor clinical outcome. We demonstrated that the deleterious impact of tumor-associated pDCs (TApDCs) is due to their impaired capacity to produce Type I interferon, which in turn potentiates...

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Detalles Bibliográficos
Autores principales: Sisirak, Vanja, Faget, Julien, Vey, Nelly, Blay, Jean-Yves, Ménétrier-Caux, Christine, Caux, Christophe, Bendriss-Vermare, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583914/
https://www.ncbi.nlm.nih.gov/pubmed/23482834
http://dx.doi.org/10.4161/onci.22338

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