Unraveling the physiological functions of exosome secretion by tumors

To understand the physiological functions of exosomes, we have recently used the inhibition of Rab27a, which prevents exosome release but also alters other secretion pathways. Our work demonstrates that the secretion of exosomes by some tumors in vivo can influence the immune microenvironment to pro...

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Detalles Bibliográficos
Autores principales: Bobrie, Angélique, Théry, Clotilde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583924/
https://www.ncbi.nlm.nih.gov/pubmed/23483742
http://dx.doi.org/10.4161/onci.22565
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author Bobrie, Angélique
Théry, Clotilde
author_facet Bobrie, Angélique
Théry, Clotilde
author_sort Bobrie, Angélique
collection PubMed
description To understand the physiological functions of exosomes, we have recently used the inhibition of Rab27a, which prevents exosome release but also alters other secretion pathways. Our work demonstrates that the secretion of exosomes by some tumors in vivo can influence the immune microenvironment to promote tumor progression, but also that this phenomenon cannot be generalized to all tumors and all exosomes.
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spelling pubmed-35839242013-03-11 Unraveling the physiological functions of exosome secretion by tumors Bobrie, Angélique Théry, Clotilde Oncoimmunology Author's View To understand the physiological functions of exosomes, we have recently used the inhibition of Rab27a, which prevents exosome release but also alters other secretion pathways. Our work demonstrates that the secretion of exosomes by some tumors in vivo can influence the immune microenvironment to promote tumor progression, but also that this phenomenon cannot be generalized to all tumors and all exosomes. Landes Bioscience 2013-01-01 /pmc/articles/PMC3583924/ /pubmed/23483742 http://dx.doi.org/10.4161/onci.22565 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Bobrie, Angélique
Théry, Clotilde
Unraveling the physiological functions of exosome secretion by tumors
title Unraveling the physiological functions of exosome secretion by tumors
title_full Unraveling the physiological functions of exosome secretion by tumors
title_fullStr Unraveling the physiological functions of exosome secretion by tumors
title_full_unstemmed Unraveling the physiological functions of exosome secretion by tumors
title_short Unraveling the physiological functions of exosome secretion by tumors
title_sort unraveling the physiological functions of exosome secretion by tumors
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583924/
https://www.ncbi.nlm.nih.gov/pubmed/23483742
http://dx.doi.org/10.4161/onci.22565
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