Predicting the efficacy of cancer vaccines by evaluating T-cell responses

In a preclinical experimental model of human papilloma virus (HPV)-induced cervical carcinoma, we have shown that the efficacy of cancer vaccines can be predicted by the evaluation of vaccine-induced T-cell responses in healthy subjects. We argue that such knowledge can be used to screen candidates...

Descripción completa

Detalles Bibliográficos
Autores principales: van Duikeren, Suzanne, Arens, Ramon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583929/
https://www.ncbi.nlm.nih.gov/pubmed/23482345
http://dx.doi.org/10.4161/onci.22616
Descripción
Sumario:In a preclinical experimental model of human papilloma virus (HPV)-induced cervical carcinoma, we have shown that the efficacy of cancer vaccines can be predicted by the evaluation of vaccine-induced T-cell responses in healthy subjects. We argue that such knowledge can be used to screen candidates for vaccination, which in turn may accelerate the development and increase the overall efficacy of cancer vaccines.

Ejemplares similares