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A prostaglandin E (PGE) receptor EP4 antagonist protects natural killer cells from PGE(2)-mediated immunosuppression and inhibits breast cancer metastasis

Cyclooxygenase-2 is frequently upregulated in epithelial tumors and contributes to poor outcomes in multiple malignancies. The COX-2 product prostaglandin E(2) (PGE(2)) promotes tumor growth and metastasis by acting on a family of four G protein-coupled receptors (EP1–4). Using a novel small molecul...

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Detalles Bibliográficos
Autores principales:	Ma, Xinrong, Holt, Dawn, Kundu, Namita, Reader, Jocelyn, Goloubeva, Olga, Take, Yukinori, Fulton, Amy M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2013
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583931/ https://www.ncbi.nlm.nih.gov/pubmed/23482441 http://dx.doi.org/10.4161/onci.22647

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