Tumor cell recognition by γδ T lymphocytes: T-cell receptor vs. NK-cell receptors

The dissection of the molecular mechanisms underlying tumor-cell recognition by γδ T-cells is crucial to improve their performance in cancer immunotherapy. Here, we discuss the controversy around the relative contributions of the γδ T-cell receptor (TCR) and natural killer receptors (NKRs) to tumor-...

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Detalles Bibliográficos
Autores principales: Correia, Daniel V., Lopes, António, Silva-Santos, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Point of View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583939/
https://www.ncbi.nlm.nih.gov/pubmed/23483102
http://dx.doi.org/10.4161/onci.22892
Descripción
Sumario:The dissection of the molecular mechanisms underlying tumor-cell recognition by γδ T-cells is crucial to improve their performance in cancer immunotherapy. Here, we discuss the controversy around the relative contributions of the γδ T-cell receptor (TCR) and natural killer receptors (NKRs) to tumor-cell targeting by γδ T cells.

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