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Noninvasive and Targeted Gene Delivery into the Brain Using Microbubble-Facilitated Focused Ultrasound
Recombinant adeno-associated viral (rAAV) vectors are potentially powerful tools for gene therapy of CNS diseases, but their penetration into brain parenchyma is severely limited by the blood-brain barrier (BBB) and current delivery relies on invasive stereotactic injection. Here we evaluate the loc...
Autores principales: | Hsu, Po-Hung, Wei, Kuo-Chen, Huang, Chiung-Yin, Wen, Chih-Jen, Yen, Tzu-Chen, Liu, Chao-Lin, Lin, Ya-Tin, Chen, Jin-Chung, Shen, Chia-Rui, Liu, Hao-Li |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584045/ https://www.ncbi.nlm.nih.gov/pubmed/23460893 http://dx.doi.org/10.1371/journal.pone.0057682 |
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