A Natural-Like Synthetic Small Molecule Impairs Bcr-Abl Signaling Cascades and Induces Megakaryocyte Differentiation in Erythroleukemia Cells

Over the past years, we synthesized a series of new molecules that are hybrids of spirocyclic ketones as complexity-bearing cores with bi- and ter-phenyls as privileged fragments. Some of these newly-shaped small molecules showed antiproliferative, pro-apoptotic and differentiating activity in leuke...

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Detalles Bibliográficos
Autores principales: Turroni, Silvia, Tolomeo, Manlio, Mamone, Gianfranco, Picariello, Gianluca, Giacomini, Elisa, Brigidi, Patrizia, Roberti, Marinella, Grimaudo, Stefania, Pipitone, Rosaria Maria, Di Cristina, Antonietta, Recanatini, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584047/
https://www.ncbi.nlm.nih.gov/pubmed/23460890
http://dx.doi.org/10.1371/journal.pone.0057650

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