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Inhibition of the NAD-Dependent Protein Deacetylase SIRT2 Induces Granulocytic Differentiation in Human Leukemia Cells

Sirtuins, NAD-dependent protein deacetylases, play important roles in cellular functions such as metabolism and differentiation. Whether sirtuins function in tumorigenesis is still controversial, but sirtuins are aberrantly expressed in tumors, which may keep cancerous cells undifferentiated. Theref...

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Detalles Bibliográficos
Autores principales:	Sunami, Yoshitaka, Araki, Marito, Hironaka, Yumi, Morishita, Soji, Kobayashi, Masaki, Liew, Ei Leen, Edahiro, Yoko, Tsutsui, Miyuki, Ohsaka, Akimichi, Komatsu, Norio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584049/ https://www.ncbi.nlm.nih.gov/pubmed/23460888 http://dx.doi.org/10.1371/journal.pone.0057633

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