Identification of Genetic Modifiers of TDP-43 Neurotoxicity in Drosophila

Cytosolic aggregation of the nuclear RNA-binding protein TDP-43 is a histopathologic signature of degenerating neurons in amyotrophic lateral sclerosis (ALS), and mutations in the TARDBP gene encoding TDP-43 cause dominantly inherited forms of this condition. To understand the relationship between T...

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Detalles Bibliográficos
Autores principales: Zhan, Lihong, Hanson, Keith A., Kim, Sang Hwa, Tare, Apeksha, Tibbetts, Randal S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584124/
https://www.ncbi.nlm.nih.gov/pubmed/23468938
http://dx.doi.org/10.1371/journal.pone.0057214

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