CNS-Targeted Production of IL-17A Induces Glial Activation, Microvascular Pathology and Enhances the Neuroinflammatory Response to Systemic Endotoxemia

Interleukin-17A (IL-17A) is a key cytokine modulating the course of inflammatory diseases. Whereas effector functions of IL-17A like induction of antimicrobial peptides and leukocyte infiltration could clearly be demonstrated for peripheral organs, CNS specific effects are not well defined and appea...

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Detalles Bibliográficos
Autores principales: Zimmermann, Julian, Krauthausen, Marius, Hofer, Markus J., Heneka, Michael T., Campbell, Iain L., Müller, Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584143/
https://www.ncbi.nlm.nih.gov/pubmed/23468966
http://dx.doi.org/10.1371/journal.pone.0057307

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