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MicroRNA regulation of natural killer cells

Natural killer (NK) cells are innate immune lymphocytes critical for host defense against viral infection and surveillance against malignant transformation. MicroRNAs (miRNAs) are a family of small, non-coding RNAs that regulate a wide variety of cellular processes. Recent advances have highlighted...

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Detalles Bibliográficos
Autores principales: Sullivan, Ryan P., Leong, Jeffrey W., Fehniger, Todd A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584293/
https://www.ncbi.nlm.nih.gov/pubmed/23450173
http://dx.doi.org/10.3389/fimmu.2013.00044
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author Sullivan, Ryan P.
Leong, Jeffrey W.
Fehniger, Todd A.
author_facet Sullivan, Ryan P.
Leong, Jeffrey W.
Fehniger, Todd A.
author_sort Sullivan, Ryan P.
collection PubMed
description Natural killer (NK) cells are innate immune lymphocytes critical for host defense against viral infection and surveillance against malignant transformation. MicroRNAs (miRNAs) are a family of small, non-coding RNAs that regulate a wide variety of cellular processes. Recent advances have highlighted the importance of miRNA-mediated post-transcriptional regulation in NK cell development, maturation, and function. This review focuses on several facets of this regulatory mechanism in NK cells: (1) the expressed NK cell miRNA transcriptome; (2) the impact of total miRNA deficiency on NK cells; (3) the role of specific miRNAs regulating NK cell development, survival, and maturation; (4) the intrinsic role of miRNAs regulating NK cell function, including cytokine production, proliferation, and cytotoxicity; and (5) the role of NK cell miRNAs in disease. Currently our knowledge of how miRNAs regulate NK cell biology is limited, and thus we also explore key open questions in the field, as well as approaches and techniques to ascertain the role of individual miRNAs as important molecular regulators.
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spelling pubmed-35842932013-02-28 MicroRNA regulation of natural killer cells Sullivan, Ryan P. Leong, Jeffrey W. Fehniger, Todd A. Front Immunol Immunology Natural killer (NK) cells are innate immune lymphocytes critical for host defense against viral infection and surveillance against malignant transformation. MicroRNAs (miRNAs) are a family of small, non-coding RNAs that regulate a wide variety of cellular processes. Recent advances have highlighted the importance of miRNA-mediated post-transcriptional regulation in NK cell development, maturation, and function. This review focuses on several facets of this regulatory mechanism in NK cells: (1) the expressed NK cell miRNA transcriptome; (2) the impact of total miRNA deficiency on NK cells; (3) the role of specific miRNAs regulating NK cell development, survival, and maturation; (4) the intrinsic role of miRNAs regulating NK cell function, including cytokine production, proliferation, and cytotoxicity; and (5) the role of NK cell miRNAs in disease. Currently our knowledge of how miRNAs regulate NK cell biology is limited, and thus we also explore key open questions in the field, as well as approaches and techniques to ascertain the role of individual miRNAs as important molecular regulators. Frontiers Media S.A. 2013-02-28 /pmc/articles/PMC3584293/ /pubmed/23450173 http://dx.doi.org/10.3389/fimmu.2013.00044 Text en Copyright © Sullivan, Leong and Fehniger. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Immunology
Sullivan, Ryan P.
Leong, Jeffrey W.
Fehniger, Todd A.
MicroRNA regulation of natural killer cells
title MicroRNA regulation of natural killer cells
title_full MicroRNA regulation of natural killer cells
title_fullStr MicroRNA regulation of natural killer cells
title_full_unstemmed MicroRNA regulation of natural killer cells
title_short MicroRNA regulation of natural killer cells
title_sort microrna regulation of natural killer cells
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584293/
https://www.ncbi.nlm.nih.gov/pubmed/23450173
http://dx.doi.org/10.3389/fimmu.2013.00044
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