Cargando…
Risk Factors in Cardiovascular Disease in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a chronic and multisystemic autoimmune disorder which predominantly affecting women. The most common cause of death in SLE patients affected by disease for more than 5 years is cardiovascular disease (CVD). Epidemiological observations suggest that, together wit...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Science Publishers
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584302/ https://www.ncbi.nlm.nih.gov/pubmed/23463953 http://dx.doi.org/10.2174/157340313805076304 |
_version_ | 1782261012563492864 |
---|---|
author | Sinicato, Nailú Angélica Cardoso, Priscila Aparecida da Silva Appenzeller, Simone |
author_facet | Sinicato, Nailú Angélica Cardoso, Priscila Aparecida da Silva Appenzeller, Simone |
author_sort | Sinicato, Nailú Angélica |
collection | PubMed |
description | Systemic lupus erythematosus (SLE) is a chronic and multisystemic autoimmune disorder which predominantly affecting women. The most common cause of death in SLE patients affected by disease for more than 5 years is cardiovascular disease (CVD). Epidemiological observations suggest that, together with classical conventional risk factors, other mechanisms (non-conventional/disease-specific factors) promote accelerated atherosclerosis in inflammatory diseases like SLE. Traditional CVD risk factors included age, hypertension, diabetes mellitus, dyslipidemia, previous vascular event defined as previous history of cerebrovascular accidents or ischemic heart disease, menopause and smoking. The non-traditional factors presents in SLE are disease-specific like renal disease manifestation as Lupus nephritis (LN), presence of pro-inflammatory cytokines, some of inflammatory mediators, antiphospholipid antibodies, anti-oxLDL antibodies, corticosteroid uses and cumulative dose of glucocorticoids. We will review traditional and non-traditional risk factors associated with CVD in SLE patients. |
format | Online Article Text |
id | pubmed-3584302 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-35843022014-02-01 Risk Factors in Cardiovascular Disease in Systemic Lupus Erythematosus Sinicato, Nailú Angélica Cardoso, Priscila Aparecida da Silva Appenzeller, Simone Curr Cardiol Rev Article Systemic lupus erythematosus (SLE) is a chronic and multisystemic autoimmune disorder which predominantly affecting women. The most common cause of death in SLE patients affected by disease for more than 5 years is cardiovascular disease (CVD). Epidemiological observations suggest that, together with classical conventional risk factors, other mechanisms (non-conventional/disease-specific factors) promote accelerated atherosclerosis in inflammatory diseases like SLE. Traditional CVD risk factors included age, hypertension, diabetes mellitus, dyslipidemia, previous vascular event defined as previous history of cerebrovascular accidents or ischemic heart disease, menopause and smoking. The non-traditional factors presents in SLE are disease-specific like renal disease manifestation as Lupus nephritis (LN), presence of pro-inflammatory cytokines, some of inflammatory mediators, antiphospholipid antibodies, anti-oxLDL antibodies, corticosteroid uses and cumulative dose of glucocorticoids. We will review traditional and non-traditional risk factors associated with CVD in SLE patients. Bentham Science Publishers 2013-02 2013-02 /pmc/articles/PMC3584302/ /pubmed/23463953 http://dx.doi.org/10.2174/157340313805076304 Text en © 2013 Bentham Science Publishers http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Sinicato, Nailú Angélica Cardoso, Priscila Aparecida da Silva Appenzeller, Simone Risk Factors in Cardiovascular Disease in Systemic Lupus Erythematosus |
title | Risk Factors in Cardiovascular Disease in Systemic Lupus Erythematosus |
title_full | Risk Factors in Cardiovascular Disease in Systemic Lupus Erythematosus |
title_fullStr | Risk Factors in Cardiovascular Disease in Systemic Lupus Erythematosus |
title_full_unstemmed | Risk Factors in Cardiovascular Disease in Systemic Lupus Erythematosus |
title_short | Risk Factors in Cardiovascular Disease in Systemic Lupus Erythematosus |
title_sort | risk factors in cardiovascular disease in systemic lupus erythematosus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584302/ https://www.ncbi.nlm.nih.gov/pubmed/23463953 http://dx.doi.org/10.2174/157340313805076304 |
work_keys_str_mv | AT sinicatonailuangelica riskfactorsincardiovasculardiseaseinsystemiclupuserythematosus AT cardosopriscilaaparecidadasilva riskfactorsincardiovasculardiseaseinsystemiclupuserythematosus AT appenzellersimone riskfactorsincardiovasculardiseaseinsystemiclupuserythematosus |