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Zingiber Officinale Alters 3,4-methylenedioxymethamphetamine-Induced Neurotoxicity in Rat Brain

OBJECTIVE: The spice Zingiber officinale or ginger possesses antioxidant activity and neuroprotective effects. The effects of this traditional herbal medicine on 3,4-methylenedioxymethamphetamine (MDMA) induced neurotoxicity have not yet been studied. The present study considers the effects of Zingi...

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Autores principales: Mehdizadeh, Mehdi, Dabaghian, Fataneh, Nejhadi, Akram, Fallah-huseini, Hassan, Choopani, Samira, Shekarriz, Nima, Molavi, Nima, Basirat, Arghavan, Mohammadzadeh Kazorgah, Farzaneh, Samzadeh-Kermani, Alireza, Soleimani Asl, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royan Institute 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584433/
https://www.ncbi.nlm.nih.gov/pubmed/23508562
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author Mehdizadeh, Mehdi
Dabaghian, Fataneh
Nejhadi, Akram
Fallah-huseini, Hassan
Choopani, Samira
Shekarriz, Nima
Molavi, Nima
Basirat, Arghavan
Mohammadzadeh Kazorgah, Farzaneh
Samzadeh-Kermani, Alireza
Soleimani Asl, Sara
author_facet Mehdizadeh, Mehdi
Dabaghian, Fataneh
Nejhadi, Akram
Fallah-huseini, Hassan
Choopani, Samira
Shekarriz, Nima
Molavi, Nima
Basirat, Arghavan
Mohammadzadeh Kazorgah, Farzaneh
Samzadeh-Kermani, Alireza
Soleimani Asl, Sara
author_sort Mehdizadeh, Mehdi
collection PubMed
description OBJECTIVE: The spice Zingiber officinale or ginger possesses antioxidant activity and neuroprotective effects. The effects of this traditional herbal medicine on 3,4-methylenedioxymethamphetamine (MDMA) induced neurotoxicity have not yet been studied. The present study considers the effects of Zingiber officinale on MDMA-induced spatial memory impairment and apoptosis in the hippocampus of male rats. MATERIALS AND METHODS: In this experimental study, 21 adult male Sprague Dawley rats (200-250 g) were classified into three groups (control, MDMA, and MDMA plus ginger). The groups were intraperitoneally administered 10 mg/kg MDMA, 10 mg/kg MDMA plus 100 mg/kg ginger extract, or 1 cc/kg normal saline as the control solution for one week (n=7 per group). Learning memory was assessed by Morris water maze (MWM) after the last administration. Finally, the brains were removed to study the cell number in the cornu ammonis (CA1) hippocampus by light microscope, Bcl-2 by immunoblotting, and Bax expression by reverse transcription polymerase chain reaction (RT-PCR). Data was analyzed using SPSS 16 software and a one-way ANOVA test. RESULTS: Escape latency and traveled distances decreased significantly in the MDMA plus ginger group relative to the MDMA group (p<0.001). Cell number increased in the MDMA plus ginger group in comparison to the MDMA group. Down-regulation of Bcl-2 and up-regulation of Bax were observed in the MDMA plus ginger group in comparison to the MDMA group (p<0.05). CONCLUSION: Our findings suggest that ginger consumption may lead to an improvement of MDMA-induced neurotoxicity.
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spelling pubmed-35844332013-03-18 Zingiber Officinale Alters 3,4-methylenedioxymethamphetamine-Induced Neurotoxicity in Rat Brain Mehdizadeh, Mehdi Dabaghian, Fataneh Nejhadi, Akram Fallah-huseini, Hassan Choopani, Samira Shekarriz, Nima Molavi, Nima Basirat, Arghavan Mohammadzadeh Kazorgah, Farzaneh Samzadeh-Kermani, Alireza Soleimani Asl, Sara Cell J Research Article OBJECTIVE: The spice Zingiber officinale or ginger possesses antioxidant activity and neuroprotective effects. The effects of this traditional herbal medicine on 3,4-methylenedioxymethamphetamine (MDMA) induced neurotoxicity have not yet been studied. The present study considers the effects of Zingiber officinale on MDMA-induced spatial memory impairment and apoptosis in the hippocampus of male rats. MATERIALS AND METHODS: In this experimental study, 21 adult male Sprague Dawley rats (200-250 g) were classified into three groups (control, MDMA, and MDMA plus ginger). The groups were intraperitoneally administered 10 mg/kg MDMA, 10 mg/kg MDMA plus 100 mg/kg ginger extract, or 1 cc/kg normal saline as the control solution for one week (n=7 per group). Learning memory was assessed by Morris water maze (MWM) after the last administration. Finally, the brains were removed to study the cell number in the cornu ammonis (CA1) hippocampus by light microscope, Bcl-2 by immunoblotting, and Bax expression by reverse transcription polymerase chain reaction (RT-PCR). Data was analyzed using SPSS 16 software and a one-way ANOVA test. RESULTS: Escape latency and traveled distances decreased significantly in the MDMA plus ginger group relative to the MDMA group (p<0.001). Cell number increased in the MDMA plus ginger group in comparison to the MDMA group. Down-regulation of Bcl-2 and up-regulation of Bax were observed in the MDMA plus ginger group in comparison to the MDMA group (p<0.05). CONCLUSION: Our findings suggest that ginger consumption may lead to an improvement of MDMA-induced neurotoxicity. Royan Institute 2012 2012-12-12 /pmc/articles/PMC3584433/ /pubmed/23508562 Text en Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Mehdizadeh, Mehdi
Dabaghian, Fataneh
Nejhadi, Akram
Fallah-huseini, Hassan
Choopani, Samira
Shekarriz, Nima
Molavi, Nima
Basirat, Arghavan
Mohammadzadeh Kazorgah, Farzaneh
Samzadeh-Kermani, Alireza
Soleimani Asl, Sara
Zingiber Officinale Alters 3,4-methylenedioxymethamphetamine-Induced Neurotoxicity in Rat Brain
title Zingiber Officinale Alters 3,4-methylenedioxymethamphetamine-Induced Neurotoxicity in Rat Brain
title_full Zingiber Officinale Alters 3,4-methylenedioxymethamphetamine-Induced Neurotoxicity in Rat Brain
title_fullStr Zingiber Officinale Alters 3,4-methylenedioxymethamphetamine-Induced Neurotoxicity in Rat Brain
title_full_unstemmed Zingiber Officinale Alters 3,4-methylenedioxymethamphetamine-Induced Neurotoxicity in Rat Brain
title_short Zingiber Officinale Alters 3,4-methylenedioxymethamphetamine-Induced Neurotoxicity in Rat Brain
title_sort zingiber officinale alters 3,4-methylenedioxymethamphetamine-induced neurotoxicity in rat brain
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584433/
https://www.ncbi.nlm.nih.gov/pubmed/23508562
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