Cargando…

Could MDMA Promote Stemness Characteristics in Mouse Embryonic Stem Cells via mGlu5 Metabotropic Glutamate Receptors?

OBJECTIVE: Ecstasy, or 3, 4 (±) methylenedioxymethamphetamine (MDMA), is a potent neurotoxic drug. One of the mechanisms for its toxicity is the secondary release of glutamate. Mouse embryonic stem cells (mESCs) express only one glutamate receptor, the metabotropic glutamate receptor 5 (mGlu5), whic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meamar, Rokhsareh, Karamali, Fereshte, Mousavi, Seyed Ali, Baharvand, Hossein, Nasr-Esfahani, Mohammad Hossein
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royan Institute 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584439/ https://www.ncbi.nlm.nih.gov/pubmed/23508940

Ejemplares similares

mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists
por: Zammataro, Magda, et al.
Publicado: (2011)

Place field stability requires the metabotropic glutamate receptor, mGlu5
por: Zhang, Sijie, et al.
Publicado: (2014)

Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice
por: Lane, Tracy A, et al.
Publicado: (2013)

Toxicity effects of methamphetamine on embryonic stem cell-derived neuron
por: Meamar, Rokhsareh, et al.
Publicado: (2012)

An Appraisal of the Influence of the Metabotropic Glutamate 5 (mGlu5) Receptor on Sociability and Anxiety
por: Ramos-Prats, Arnau, et al.
Publicado: (2019)

Phosphorylation and regulation of group II metabotropic glutamate receptors (mGlu2/3) in neurons
por: Mao, Li-Min, et al.
Publicado: (2022)

Tetrahydronaphthyridine and Dihydronaphthyridinone Ethers As Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 5 (mGlu(5))
por: Turlington, Mark, et al.
Publicado: (2014)

Altered Short-Term Synaptic Plasticity in Mice Lacking the Metabotropic Glutamate Receptor mGlu7
por: Bushell, Trevor J., et al.
Publicado: (2002)

Protein Networks Associated with Native Metabotropic Glutamate 1 Receptors (mGlu(1)) in the Mouse Cerebellum
por: Mansouri, Mahnaz, et al.
Publicado: (2023)

The Metabotropic Glutamate Receptor, mGlu5, Is Required for Extinction Learning That Occurs in the Absence of a Context Change
por: André, Marion Agnes Emma, et al.
Publicado: (2015)

Targeting mGlu5 Metabotropic Glutamate Receptors in the Treatment of Cognitive Dysfunction in a Mouse Model of Phenylketonuria
por: Nardecchia, Francesca, et al.
Publicado: (2018)

Glutamate Metabotropic Receptor Type 3 (mGlu3) Localization in the Rat Prelimbic Medial Prefrontal Cortex
por: Woo, Elizabeth, et al.
Publicado: (2022)

Monitoring the induction of ferroptosis following dissociation in human embryonic stem cells
por: Babaei-Abraki, Shahnaz, et al.
Publicado: (2022)

Deletion of Metabotropic Glutamate Receptors 2 and 3 (mGlu2 & mGlu3) in Mice Disrupts Sleep and Wheel-Running Activity, and Increases the Sensitivity of the Circadian System to Light
por: Pritchett, David, et al.
Publicado: (2015)

A group II metabotropic glutamate receptor 3 (mGlu3, GRM3) isoform implicated in schizophrenia interacts with canonical mGlu3 and reduces ligand binding
por: García-Bea, Aintzane, et al.
Publicado: (2017)

Xanthurenic Acid Activates mGlu2/3 Metabotropic Glutamate Receptors and is a Potential Trait Marker for Schizophrenia
por: Fazio, Francesco, et al.
Publicado: (2015)

Genetic Deletion of mGlu3 Metabotropic Glutamate Receptors Amplifies Ischemic Brain Damage and Associated Neuroinflammation in Mice
por: Mastroiacovo, Federica, et al.
Publicado: (2021)

mGlu3 Metabotropic Glutamate Receptors as a Target for the Treatment of Absence Epilepsy: Preclinical and Human Genetics Data
por: Celli, Roberta, et al.
Publicado: (2023)

Structural insights into dimerization and activation of the mGlu2–mGlu3 and mGlu2–mGlu4 heterodimers
por: Wang, Xinwei, et al.
Publicado: (2023)

Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia
por: Mastroiacovo, Federica, et al.
Publicado: (2017)

Fractionation of Spatial Memory in GRM2/3 (mGlu2/mGlu3) Double Knockout Mice Reveals a Role for Group II Metabotropic Glutamate Receptors at the Interface Between Arousal and Cognition
por: Lyon, Louisa, et al.
Publicado: (2011)

Radiosynthesis and Evaluation of an (18)F-Labeled Positron Emission Tomography (PET) Radioligand for Metabotropic Glutamate Receptor Subtype 4 (mGlu(4))
por: Kil, Kun-Eek, et al.
Publicado: (2014)

Metabotropic glutamate receptor 3 (mGlu3; mGluR3; GRM3) in schizophrenia: Antibody characterisation and a semi-quantitative western blot study
por: García-Bea, Aintzane, et al.
Publicado: (2016)

Comparing Three Methods of Co-culture of Retinal Pigment Epithelium with Progenitor Cells Derived Human Embryonic Stem Cells
por: Amirpour, Noushin, et al.
Publicado: (2013)

Functional expression of potassium channels in cardiomyocytes derived from embryonic stem cells
por: Abtahi, S.R., et al.
Publicado: (2012)

Analysis of Promyelocytic Leukemia in Human Embryonic Carcinoma Stem Cells During Retinoic Acid-Induced Neural Differentiation
por: Karbalaie, Khadijeh, et al.
Publicado: (2016)

Purinergic Receptor Expression and Potential Association with Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cell Development
por: Kashfi, Shirin, et al.
Publicado: (2017)

Pharmacological enhancement of mGlu1 metabotropic glutamate receptors causes a prolonged symptomatic benefit in a mouse model of spinocerebellar ataxia type 1
por: Notartomaso, Serena, et al.
Publicado: (2013)

43.1 GENETIC INSIGHTS LEAD TO DISCOVERY OF SELECTIVE ACTIVATORS OF MGLU1 AND MGLU3 METABOTROPIC GLUTAMATE RECEPTORS AS POTENTIAL TREATMENTS FOR SCHIZOPHRENIA
por: Conn, P Jeffrey, et al.
Publicado: (2018)

Stem Cells from Human Exfoliated Deciduous Tooth Exhibit Stromal-Derived Inducing Activity and Lead to Generation of Neural Crest Cells from Human Embryonic Stem Cells
por: Karbalaie, Khadijeh, et al.
Publicado: (2015)

Stem Cells from Human Exfoliated Deciduous Tooth Exhibit Stromal-Derived Inducing Activity and Lead to Generation of Neural Crest Cells from Human Embryonic Stem Cells
por: Karbalaie, Khadijeh, et al.
Publicado: (2021)

A large consanguineous family with a homozygous Metabotropic Glutamate Receptor 7 (mGlu7) variant and developmental epileptic encephalopathy: Effect on protein structure and ligand affinity
por: Jdila, Marwa Ben, et al.
Publicado: (2021)

Allosteric Modulators for mGlu Receptors
por: Gasparini, F, et al.
Publicado: (2007)

Metabotropic glutamate receptor 5 (mGluR5) regulates bladder nociception
por: Crock, Lara W, et al.
Publicado: (2012)

Mechanisms Associated with Activation of Intracellular Metabotropic Glutamate Receptor, mGluR5
por: Jong, Yuh-Jiin I., et al.
Publicado: (2016)

Emotional Impairment and Persistent Upregulation of mGlu(5) Receptor following Morphine Abstinence: Implications of an mGlu(5)-MOPr Interaction
por: Zanos, Panos, et al.
Publicado: (2016)

mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors
por: Notartomaso, Serena, et al.
Publicado: (2018)

mGlu5 Receptor Functional Interactions and Addiction
por: Brown, Robyn M., et al.
Publicado: (2012)

Design and Synthesis of Systemically Active Metabotropic Glutamate Subtype-2 and -3 (mGlu(2/3)) Receptor Positive Allosteric Modulators (PAMs): Pharmacological Characterization and Assessment in a Rat Model of Cocaine Dependence
por: Dhanya, Raveendra-Panickar, et al.
Publicado: (2014)

Data for whole and mitochondrial proteome of human embryonic stem cells
por: Shekari, Faezeh, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_mvg52cn7p1q32g4ni7om5jkv6g