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The curcumin analogue hydrazinocurcumin exhibits potent suppressive activity on carcinogenicity of breast cancer cells via STAT3 inhibition
Curcumin, the active component of turmeric, has been shown to protect against carcinogenesis and prevent tumor development in cancer. In our study, we tested the efficacy of a synthetic curcumin analogue, known as hydrazinocurcumin (HC), in breast cancer cells. The results demonstrated that compared...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584822/ https://www.ncbi.nlm.nih.gov/pubmed/22179587 http://dx.doi.org/10.3892/ijo.2011.1298 |
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author | WANG, XIAOFEI ZHANG, YAN ZHANG, XIWEN TIAN, WENXIA FENG, WENLI CHEN, TINGMEI |
author_facet | WANG, XIAOFEI ZHANG, YAN ZHANG, XIWEN TIAN, WENXIA FENG, WENLI CHEN, TINGMEI |
author_sort | WANG, XIAOFEI |
collection | PubMed |
description | Curcumin, the active component of turmeric, has been shown to protect against carcinogenesis and prevent tumor development in cancer. In our study, we tested the efficacy of a synthetic curcumin analogue, known as hydrazinocurcumin (HC), in breast cancer cells. The results demonstrated that compared to curcumin, HC was more effective in inhibiting STAT3 phosphorylation and downregulation of an array of STAT3 downstream targets which contributed to suppression of cell proliferation, loss of colony formation, depression of cell migration and invasion as well as induction of cell apoptosis. It was concluded that HC is a potent agent in the inhibition of STAT3 with more favorable pharmacological activity than curcumin, and HC may have translational potential as an effective cancer therapeutic or preventive agent for human breast carcinoma. |
format | Online Article Text |
id | pubmed-3584822 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-35848222013-03-04 The curcumin analogue hydrazinocurcumin exhibits potent suppressive activity on carcinogenicity of breast cancer cells via STAT3 inhibition WANG, XIAOFEI ZHANG, YAN ZHANG, XIWEN TIAN, WENXIA FENG, WENLI CHEN, TINGMEI Int J Oncol Articles Curcumin, the active component of turmeric, has been shown to protect against carcinogenesis and prevent tumor development in cancer. In our study, we tested the efficacy of a synthetic curcumin analogue, known as hydrazinocurcumin (HC), in breast cancer cells. The results demonstrated that compared to curcumin, HC was more effective in inhibiting STAT3 phosphorylation and downregulation of an array of STAT3 downstream targets which contributed to suppression of cell proliferation, loss of colony formation, depression of cell migration and invasion as well as induction of cell apoptosis. It was concluded that HC is a potent agent in the inhibition of STAT3 with more favorable pharmacological activity than curcumin, and HC may have translational potential as an effective cancer therapeutic or preventive agent for human breast carcinoma. D.A. Spandidos 2011-12-14 /pmc/articles/PMC3584822/ /pubmed/22179587 http://dx.doi.org/10.3892/ijo.2011.1298 Text en Copyright © 2012, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles WANG, XIAOFEI ZHANG, YAN ZHANG, XIWEN TIAN, WENXIA FENG, WENLI CHEN, TINGMEI The curcumin analogue hydrazinocurcumin exhibits potent suppressive activity on carcinogenicity of breast cancer cells via STAT3 inhibition |
title | The curcumin analogue hydrazinocurcumin exhibits potent suppressive activity on carcinogenicity of breast cancer cells via STAT3 inhibition |
title_full | The curcumin analogue hydrazinocurcumin exhibits potent suppressive activity on carcinogenicity of breast cancer cells via STAT3 inhibition |
title_fullStr | The curcumin analogue hydrazinocurcumin exhibits potent suppressive activity on carcinogenicity of breast cancer cells via STAT3 inhibition |
title_full_unstemmed | The curcumin analogue hydrazinocurcumin exhibits potent suppressive activity on carcinogenicity of breast cancer cells via STAT3 inhibition |
title_short | The curcumin analogue hydrazinocurcumin exhibits potent suppressive activity on carcinogenicity of breast cancer cells via STAT3 inhibition |
title_sort | curcumin analogue hydrazinocurcumin exhibits potent suppressive activity on carcinogenicity of breast cancer cells via stat3 inhibition |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584822/ https://www.ncbi.nlm.nih.gov/pubmed/22179587 http://dx.doi.org/10.3892/ijo.2011.1298 |
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