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Epigenetic mechanisms in migraine: a promising avenue?
Migraine is a disabling common brain disorder typically characterized by attacks of severe headache and associated with autonomic and neurological symptoms. Its etiology is far from resolved. This review will focus on evidence that epigenetic mechanisms play an important role in disease etiology. Ep...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584973/ https://www.ncbi.nlm.nih.gov/pubmed/23379668 http://dx.doi.org/10.1186/1741-7015-11-26 |
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author | Eising, Else A Datson, Nicole van den Maagdenberg, Arn MJM Ferrari, Michel D |
author_facet | Eising, Else A Datson, Nicole van den Maagdenberg, Arn MJM Ferrari, Michel D |
author_sort | Eising, Else |
collection | PubMed |
description | Migraine is a disabling common brain disorder typically characterized by attacks of severe headache and associated with autonomic and neurological symptoms. Its etiology is far from resolved. This review will focus on evidence that epigenetic mechanisms play an important role in disease etiology. Epigenetics comprise both DNA methylation and post-translational modifications of the tails of histone proteins, affecting chromatin structure and gene expression. Besides playing a role in establishing cellular and developmental stage-specific regulation of gene expression, epigenetic processes are also important for programming lasting cellular responses to environmental signals. Epigenetic mechanisms may explain how non-genetic endogenous and exogenous factors such as female sex hormones, stress hormones and inflammation trigger may modulate attack frequency. Developing drugs that specifically target epigenetic mechanisms may open up exciting new avenues for the prophylactic treatment of migraine. |
format | Online Article Text |
id | pubmed-3584973 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35849732013-03-11 Epigenetic mechanisms in migraine: a promising avenue? Eising, Else A Datson, Nicole van den Maagdenberg, Arn MJM Ferrari, Michel D BMC Med Minireview Migraine is a disabling common brain disorder typically characterized by attacks of severe headache and associated with autonomic and neurological symptoms. Its etiology is far from resolved. This review will focus on evidence that epigenetic mechanisms play an important role in disease etiology. Epigenetics comprise both DNA methylation and post-translational modifications of the tails of histone proteins, affecting chromatin structure and gene expression. Besides playing a role in establishing cellular and developmental stage-specific regulation of gene expression, epigenetic processes are also important for programming lasting cellular responses to environmental signals. Epigenetic mechanisms may explain how non-genetic endogenous and exogenous factors such as female sex hormones, stress hormones and inflammation trigger may modulate attack frequency. Developing drugs that specifically target epigenetic mechanisms may open up exciting new avenues for the prophylactic treatment of migraine. BioMed Central 2013-02-04 /pmc/articles/PMC3584973/ /pubmed/23379668 http://dx.doi.org/10.1186/1741-7015-11-26 Text en Copyright ©2013 Eising et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Minireview Eising, Else A Datson, Nicole van den Maagdenberg, Arn MJM Ferrari, Michel D Epigenetic mechanisms in migraine: a promising avenue? |
title | Epigenetic mechanisms in migraine: a promising avenue? |
title_full | Epigenetic mechanisms in migraine: a promising avenue? |
title_fullStr | Epigenetic mechanisms in migraine: a promising avenue? |
title_full_unstemmed | Epigenetic mechanisms in migraine: a promising avenue? |
title_short | Epigenetic mechanisms in migraine: a promising avenue? |
title_sort | epigenetic mechanisms in migraine: a promising avenue? |
topic | Minireview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584973/ https://www.ncbi.nlm.nih.gov/pubmed/23379668 http://dx.doi.org/10.1186/1741-7015-11-26 |
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