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Conditional Inactivation of the DNA Damage Response Gene Hus1 in Mouse Testis Reveals Separable Roles for Components of the RAD9-RAD1-HUS1 Complex in Meiotic Chromosome Maintenance
The RAD9-RAD1-HUS1 (9-1-1) complex is a heterotrimeric PCNA-like clamp that responds to DNA damage in somatic cells by promoting DNA repair as well as ATR-dependent DNA damage checkpoint signaling. In yeast, worms, and flies, the 9-1-1 complex is also required for meiotic checkpoint function and eff...
Autores principales: | Lyndaker, Amy M., Lim, Pei Xin, Mleczko, Joanna M., Diggins, Catherine E., Holloway, J. Kim, Holmes, Rebecca J., Kan, Rui, Schlafer, Donald H., Freire, Raimundo, Cohen, Paula E., Weiss, Robert S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585019/ https://www.ncbi.nlm.nih.gov/pubmed/23468651 http://dx.doi.org/10.1371/journal.pgen.1003320 |
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