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The CENP-A nucleosome: A battle between Dr Jekyll and Mr Hyde
The structure of the centromere-specific histone centromeric protein A (CENP-A) nucleosome has been a hot topic of debate for the past five years. Structures proposed include octamers, hexamers, homotypic and heterotypic tetramers. This controversy has led to the proposal that CENP-A nucleosomes und...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585026/ https://www.ncbi.nlm.nih.gov/pubmed/23324462 http://dx.doi.org/10.4161/nucl.23588 |
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author | Bui, Minh Walkiewicz, Marcin P. Dimitriadis, Emilios K. Dalal, Yamini |
author_facet | Bui, Minh Walkiewicz, Marcin P. Dimitriadis, Emilios K. Dalal, Yamini |
author_sort | Bui, Minh |
collection | PubMed |
description | The structure of the centromere-specific histone centromeric protein A (CENP-A) nucleosome has been a hot topic of debate for the past five years. Structures proposed include octamers, hexamers, homotypic and heterotypic tetramers. This controversy has led to the proposal that CENP-A nucleosomes undergo cell-cycle dependent transitions between the multiple states previously documented to exist in vivo and in vitro. In recent work from our laboratory, we sought to test this hypothesis. We discovered that CENP-A nucleosomes undergo unique oscillations in human cells, a finding mirrored in a parallel study performed in budding yeast. This review provides additional insights into the potential mechanisms for the interconversion of CENP-A nucleosomal species, and speculates on a biological role for oscillations in vivo. |
format | Online Article Text |
id | pubmed-3585026 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-35850262013-03-11 The CENP-A nucleosome: A battle between Dr Jekyll and Mr Hyde Bui, Minh Walkiewicz, Marcin P. Dimitriadis, Emilios K. Dalal, Yamini Nucleus Extra View The structure of the centromere-specific histone centromeric protein A (CENP-A) nucleosome has been a hot topic of debate for the past five years. Structures proposed include octamers, hexamers, homotypic and heterotypic tetramers. This controversy has led to the proposal that CENP-A nucleosomes undergo cell-cycle dependent transitions between the multiple states previously documented to exist in vivo and in vitro. In recent work from our laboratory, we sought to test this hypothesis. We discovered that CENP-A nucleosomes undergo unique oscillations in human cells, a finding mirrored in a parallel study performed in budding yeast. This review provides additional insights into the potential mechanisms for the interconversion of CENP-A nucleosomal species, and speculates on a biological role for oscillations in vivo. Landes Bioscience 2013-01-01 /pmc/articles/PMC3585026/ /pubmed/23324462 http://dx.doi.org/10.4161/nucl.23588 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Extra View Bui, Minh Walkiewicz, Marcin P. Dimitriadis, Emilios K. Dalal, Yamini The CENP-A nucleosome: A battle between Dr Jekyll and Mr Hyde |
title | The CENP-A nucleosome: A battle between Dr Jekyll and Mr Hyde |
title_full | The CENP-A nucleosome: A battle between Dr Jekyll and Mr Hyde |
title_fullStr | The CENP-A nucleosome: A battle between Dr Jekyll and Mr Hyde |
title_full_unstemmed | The CENP-A nucleosome: A battle between Dr Jekyll and Mr Hyde |
title_short | The CENP-A nucleosome: A battle between Dr Jekyll and Mr Hyde |
title_sort | cenp-a nucleosome: a battle between dr jekyll and mr hyde |
topic | Extra View |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585026/ https://www.ncbi.nlm.nih.gov/pubmed/23324462 http://dx.doi.org/10.4161/nucl.23588 |
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