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The CENP-A nucleosome: A battle between Dr Jekyll and Mr Hyde

The structure of the centromere-specific histone centromeric protein A (CENP-A) nucleosome has been a hot topic of debate for the past five years. Structures proposed include octamers, hexamers, homotypic and heterotypic tetramers. This controversy has led to the proposal that CENP-A nucleosomes und...

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Detalles Bibliográficos
Autores principales: Bui, Minh, Walkiewicz, Marcin P., Dimitriadis, Emilios K., Dalal, Yamini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585026/
https://www.ncbi.nlm.nih.gov/pubmed/23324462
http://dx.doi.org/10.4161/nucl.23588
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author Bui, Minh
Walkiewicz, Marcin P.
Dimitriadis, Emilios K.
Dalal, Yamini
author_facet Bui, Minh
Walkiewicz, Marcin P.
Dimitriadis, Emilios K.
Dalal, Yamini
author_sort Bui, Minh
collection PubMed
description The structure of the centromere-specific histone centromeric protein A (CENP-A) nucleosome has been a hot topic of debate for the past five years. Structures proposed include octamers, hexamers, homotypic and heterotypic tetramers. This controversy has led to the proposal that CENP-A nucleosomes undergo cell-cycle dependent transitions between the multiple states previously documented to exist in vivo and in vitro. In recent work from our laboratory, we sought to test this hypothesis. We discovered that CENP-A nucleosomes undergo unique oscillations in human cells, a finding mirrored in a parallel study performed in budding yeast. This review provides additional insights into the potential mechanisms for the interconversion of CENP-A nucleosomal species, and speculates on a biological role for oscillations in vivo.
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spelling pubmed-35850262013-03-11 The CENP-A nucleosome: A battle between Dr Jekyll and Mr Hyde Bui, Minh Walkiewicz, Marcin P. Dimitriadis, Emilios K. Dalal, Yamini Nucleus Extra View The structure of the centromere-specific histone centromeric protein A (CENP-A) nucleosome has been a hot topic of debate for the past five years. Structures proposed include octamers, hexamers, homotypic and heterotypic tetramers. This controversy has led to the proposal that CENP-A nucleosomes undergo cell-cycle dependent transitions between the multiple states previously documented to exist in vivo and in vitro. In recent work from our laboratory, we sought to test this hypothesis. We discovered that CENP-A nucleosomes undergo unique oscillations in human cells, a finding mirrored in a parallel study performed in budding yeast. This review provides additional insights into the potential mechanisms for the interconversion of CENP-A nucleosomal species, and speculates on a biological role for oscillations in vivo. Landes Bioscience 2013-01-01 /pmc/articles/PMC3585026/ /pubmed/23324462 http://dx.doi.org/10.4161/nucl.23588 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Extra View
Bui, Minh
Walkiewicz, Marcin P.
Dimitriadis, Emilios K.
Dalal, Yamini
The CENP-A nucleosome: A battle between Dr Jekyll and Mr Hyde
title The CENP-A nucleosome: A battle between Dr Jekyll and Mr Hyde
title_full The CENP-A nucleosome: A battle between Dr Jekyll and Mr Hyde
title_fullStr The CENP-A nucleosome: A battle between Dr Jekyll and Mr Hyde
title_full_unstemmed The CENP-A nucleosome: A battle between Dr Jekyll and Mr Hyde
title_short The CENP-A nucleosome: A battle between Dr Jekyll and Mr Hyde
title_sort cenp-a nucleosome: a battle between dr jekyll and mr hyde
topic Extra View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585026/
https://www.ncbi.nlm.nih.gov/pubmed/23324462
http://dx.doi.org/10.4161/nucl.23588
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