Bactericidal Activity Does Not Predict Sterilizing Activity: The Case of Rifapentine in the Murine Model of Mycobacterium ulcerans Disease

BACKGROUND: Since 2004, treatment of Mycobacterium ulcerans disease, or Buruli ulcer, has shifted from surgery to daily treatment with streptomycin (STR) + rifampin (RIF) for 8 weeks. For shortening treatment duration, we tested the potential of daily rifapentine (RPT), a long-acting rifamycin deriv...

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Detalles Bibliográficos
Autores principales: Almeida, Deepak V., Converse, Paul J., Li, Si-Yang, Tyagi, Sandeep, Nuermberger, Eric L., Grosset, Jacques H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585034/
https://www.ncbi.nlm.nih.gov/pubmed/23469308
http://dx.doi.org/10.1371/journal.pntd.0002085

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