A Genome-Wide RNAi Screen in Caenorhabditis elegans Identifies the Nicotinic Acetylcholine Receptor Subunit ACR-7 as an Antipsychotic Drug Target

We report a genome-wide RNA interference (RNAi) screen for Suppressors of Clozapine-induced Larval Arrest (scla genes) in Caenorhabditis elegans, the first genetic suppressor screen for antipsychotic drug (APD) targets in an animal. The screen identifies 40 suppressors, including the α-like nicotini...

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Detalles Bibliográficos
Autores principales: Saur, Taixiang, DeMarco, Sarah E., Ortiz, Angelica, Sliwoski, Gregory R., Hao, Limin, Wang, Xin, Cohen, Bruce M., Buttner, Edgar A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585123/
https://www.ncbi.nlm.nih.gov/pubmed/23468647
http://dx.doi.org/10.1371/journal.pgen.1003313

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