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The Amidation Step of Diphthamide Biosynthesis in Yeast Requires DPH6, a Gene Identified through Mining the DPH1-DPH5 Interaction Network

Diphthamide is a highly modified histidine residue in eukaryal translation elongation factor 2 (eEF2) that is the target for irreversible ADP ribosylation by diphtheria toxin (DT). In Saccharomyces cerevisiae, the initial steps of diphthamide biosynthesis are well characterized and require the DPH1-...

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Detalles Bibliográficos
Autores principales:	Uthman, Shanow, Bär, Christian, Scheidt, Viktor, Liu, Shihui, ten Have, Sara, Giorgini, Flaviano, Stark, Michael J. R., Schaffrath, Raffael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585130/ https://www.ncbi.nlm.nih.gov/pubmed/23468660 http://dx.doi.org/10.1371/journal.pgen.1003334

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