Irreversible Renal Damage after Transient Renin-Angiotensin System Stimulation: Involvement of an AT(1)-Receptor Mediated Immune Response

Transient activation of the renin-angiotensin system (RAS) induces irreversible renal damage causing sustained elevation in blood pressure (BP) in Cyp1a1-Ren2 transgenic rats. In our current study we hypothesized that activation of the AT(1)-receptor (AT(1)R) leads to a T-cell response causing irrev...

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Detalles Bibliográficos
Autores principales: Heijnen, Bart F. J., Nelissen, Jelly, van Essen, Helma, Fazzi, Gregorio E., Cohen Tervaert, Jan W., Peutz-Kootstra, Carine J., Mullins, John J., Schalkwijk, Casper G., Janssen, Ben J. A., Struijker-Boudier, Harry AJ.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585138/
https://www.ncbi.nlm.nih.gov/pubmed/23469072
http://dx.doi.org/10.1371/journal.pone.0057815

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