Cargando…
Increased Functional Stability and Homogeneity of Viral Envelope Spikes through Directed Evolution
The functional HIV-1 envelope glycoprotein (Env) trimer, the target of anti-HIV-1 neutralizing antibodies (Abs), is innately labile and coexists with non-native forms of Env. This lability and heterogeneity in Env has been associated with its tendency to elicit non-neutralizing Abs. Here, we use dir...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585149/ https://www.ncbi.nlm.nih.gov/pubmed/23468626 http://dx.doi.org/10.1371/journal.ppat.1003184 |