Poxvirus Targeting of E3 Ligase β-TrCP by Molecular Mimicry: A Mechanism to Inhibit NF-κB Activation and Promote Immune Evasion and Virulence

The transcription factor NF-κB is essential for immune responses against pathogens and its activation requires the phosphorylation, ubiquitination and proteasomal degradation of IκBα. Here we describe an inhibitor of NF-κB from vaccinia virus that has a closely related counterpart in variola virus,...

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Detalles Bibliográficos
Autores principales: Mansur, Daniel S., Maluquer de Motes, Carlos, Unterholzner, Leonie, Sumner, Rebecca P., Ferguson, Brian J., Ren, Hongwei, Strnadova, Pavla, Bowie, Andrew G., Smith, Geoffrey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585151/
https://www.ncbi.nlm.nih.gov/pubmed/23468625
http://dx.doi.org/10.1371/journal.ppat.1003183

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