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Endothelin-2-Mediated Protection of Mutant Photoreceptors in Inherited Photoreceptor Degeneration
Expression of the Endothelin-2 (Edn2) mRNA is greatly increased in the photoreceptors (PRs) of mouse models of inherited PR degeneration (IPD). To examine the role of Edn2 in mutant PR survival, we generated Edn2(−/−) mice carrying homozygous Pde6b(rd1) alleles or the Tg(RHO P347S) transgene. In the...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585171/ https://www.ncbi.nlm.nih.gov/pubmed/23469133 http://dx.doi.org/10.1371/journal.pone.0058023 |