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Use of a Modified Spatial-Context Memory Test to Detect Amnestic Mild Cognitive Impairment
In this study we sought to differentiate participants with amnestic mild cognitive impairment (a-MCI) from those with mild dementia of Alzheimer’s type (m-DAT) and normal controls by modifying an existing test of spatial context memory (SCMT) designed so as to evaluate the function of brain regions...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585255/ https://www.ncbi.nlm.nih.gov/pubmed/23468906 http://dx.doi.org/10.1371/journal.pone.0057030 |
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author | Wang, Hsuan-Min Yang, Chien-Ming Kuo, Wan-Chin Huang, Chin-Chang Kuo, Hung-Chou |
author_facet | Wang, Hsuan-Min Yang, Chien-Ming Kuo, Wan-Chin Huang, Chin-Chang Kuo, Hung-Chou |
author_sort | Wang, Hsuan-Min |
collection | PubMed |
description | In this study we sought to differentiate participants with amnestic mild cognitive impairment (a-MCI) from those with mild dementia of Alzheimer’s type (m-DAT) and normal controls by modifying an existing test of spatial context memory (SCMT) designed so as to evaluate the function of brain regions affected in early m-DAT. We found that participants with a-MCI had better total scores on our modified SCMT than those with m-DAT. Furthermore, the locational memory subtest was able to discriminate between those with a-MCI and m-DAT. Additionally, compared with other screening tests, our spatial context memory test showed high sensitivity and specificity in discerning those with a-MCI from the normal population but, was relatively ineffective in discriminating a-MCI patients from those with m-DAT. We conclude that our modified test of SCMT is an effective tool for discriminating a-MCI from m-DAT and does so by detecting differences in locational memory. |
format | Online Article Text |
id | pubmed-3585255 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-35852552013-03-06 Use of a Modified Spatial-Context Memory Test to Detect Amnestic Mild Cognitive Impairment Wang, Hsuan-Min Yang, Chien-Ming Kuo, Wan-Chin Huang, Chin-Chang Kuo, Hung-Chou PLoS One Research Article In this study we sought to differentiate participants with amnestic mild cognitive impairment (a-MCI) from those with mild dementia of Alzheimer’s type (m-DAT) and normal controls by modifying an existing test of spatial context memory (SCMT) designed so as to evaluate the function of brain regions affected in early m-DAT. We found that participants with a-MCI had better total scores on our modified SCMT than those with m-DAT. Furthermore, the locational memory subtest was able to discriminate between those with a-MCI and m-DAT. Additionally, compared with other screening tests, our spatial context memory test showed high sensitivity and specificity in discerning those with a-MCI from the normal population but, was relatively ineffective in discriminating a-MCI patients from those with m-DAT. We conclude that our modified test of SCMT is an effective tool for discriminating a-MCI from m-DAT and does so by detecting differences in locational memory. Public Library of Science 2013-02-28 /pmc/articles/PMC3585255/ /pubmed/23468906 http://dx.doi.org/10.1371/journal.pone.0057030 Text en © 2013 Wang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Wang, Hsuan-Min Yang, Chien-Ming Kuo, Wan-Chin Huang, Chin-Chang Kuo, Hung-Chou Use of a Modified Spatial-Context Memory Test to Detect Amnestic Mild Cognitive Impairment |
title | Use of a Modified Spatial-Context Memory Test to Detect Amnestic Mild Cognitive Impairment |
title_full | Use of a Modified Spatial-Context Memory Test to Detect Amnestic Mild Cognitive Impairment |
title_fullStr | Use of a Modified Spatial-Context Memory Test to Detect Amnestic Mild Cognitive Impairment |
title_full_unstemmed | Use of a Modified Spatial-Context Memory Test to Detect Amnestic Mild Cognitive Impairment |
title_short | Use of a Modified Spatial-Context Memory Test to Detect Amnestic Mild Cognitive Impairment |
title_sort | use of a modified spatial-context memory test to detect amnestic mild cognitive impairment |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585255/ https://www.ncbi.nlm.nih.gov/pubmed/23468906 http://dx.doi.org/10.1371/journal.pone.0057030 |
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