High Expression of Lewis y Antigen and CD44 Is Correlated with Resistance to Chemotherapy in Epithelial Ovarian Cancers

OBJECTIVES: To measure Lewis y antigen and CD44 antigen expression in epithelial ovarian carcinoma and to correlate the levels of these antigens with clinical response to chemotherapy. METHODS: The study cases included 34 cases of ovarian carcinoma with resistance to chemotherapeutic drugs, 6 partia...

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Detalles Bibliográficos
Autores principales: Hu, Zhenhua, Gao, Jian, Zhang, Danye, Liu, Qing, Yan, Limei, Gao, Lili, Liu, Juanjuan, Liu, Dawo, Zhang, Shulan, Lin, Bei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585297/
https://www.ncbi.nlm.nih.gov/pubmed/23468946
http://dx.doi.org/10.1371/journal.pone.0057250
Descripción
Sumario:OBJECTIVES: To measure Lewis y antigen and CD44 antigen expression in epithelial ovarian carcinoma and to correlate the levels of these antigens with clinical response to chemotherapy. METHODS: The study cases included 34 cases of ovarian carcinoma with resistance to chemotherapeutic drugs, 6 partially drug-sensitive cases, and 52 drug-sensitive cases (92 total). RESULTS: The rates of expression of Lewis y antigen and CD44 antigen were significantly greater in the drug-resistant group than that in the partially-sensitive or sensitive groups. Surgical stage, residual tumor size and expression of CD44 and Lewis y antigen in ovarian carcinoma tissues were independent risk factors for chemotherapeutic drug resistance. CONCLUSIONS: Over-expression of Lewis y and CD44 antigen are strong risk factors for chemotherapeutic drug resistance in ovarian carcinoma patients.

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