High Expression of Lewis y Antigen and CD44 Is Correlated with Resistance to Chemotherapy in Epithelial Ovarian Cancers

OBJECTIVES: To measure Lewis y antigen and CD44 antigen expression in epithelial ovarian carcinoma and to correlate the levels of these antigens with clinical response to chemotherapy. METHODS: The study cases included 34 cases of ovarian carcinoma with resistance to chemotherapeutic drugs, 6 partia...

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Autores principales: Hu, Zhenhua, Gao, Jian, Zhang, Danye, Liu, Qing, Yan, Limei, Gao, Lili, Liu, Juanjuan, Liu, Dawo, Zhang, Shulan, Lin, Bei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585297/
https://www.ncbi.nlm.nih.gov/pubmed/23468946
http://dx.doi.org/10.1371/journal.pone.0057250
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author Hu, Zhenhua
Gao, Jian
Zhang, Danye
Liu, Qing
Yan, Limei
Gao, Lili
Liu, Juanjuan
Liu, Dawo
Zhang, Shulan
Lin, Bei
author_facet Hu, Zhenhua
Gao, Jian
Zhang, Danye
Liu, Qing
Yan, Limei
Gao, Lili
Liu, Juanjuan
Liu, Dawo
Zhang, Shulan
Lin, Bei
author_sort Hu, Zhenhua
collection PubMed
description OBJECTIVES: To measure Lewis y antigen and CD44 antigen expression in epithelial ovarian carcinoma and to correlate the levels of these antigens with clinical response to chemotherapy. METHODS: The study cases included 34 cases of ovarian carcinoma with resistance to chemotherapeutic drugs, 6 partially drug-sensitive cases, and 52 drug-sensitive cases (92 total). RESULTS: The rates of expression of Lewis y antigen and CD44 antigen were significantly greater in the drug-resistant group than that in the partially-sensitive or sensitive groups. Surgical stage, residual tumor size and expression of CD44 and Lewis y antigen in ovarian carcinoma tissues were independent risk factors for chemotherapeutic drug resistance. CONCLUSIONS: Over-expression of Lewis y and CD44 antigen are strong risk factors for chemotherapeutic drug resistance in ovarian carcinoma patients.
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spelling pubmed-35852972013-03-06 High Expression of Lewis y Antigen and CD44 Is Correlated with Resistance to Chemotherapy in Epithelial Ovarian Cancers Hu, Zhenhua Gao, Jian Zhang, Danye Liu, Qing Yan, Limei Gao, Lili Liu, Juanjuan Liu, Dawo Zhang, Shulan Lin, Bei PLoS One Research Article OBJECTIVES: To measure Lewis y antigen and CD44 antigen expression in epithelial ovarian carcinoma and to correlate the levels of these antigens with clinical response to chemotherapy. METHODS: The study cases included 34 cases of ovarian carcinoma with resistance to chemotherapeutic drugs, 6 partially drug-sensitive cases, and 52 drug-sensitive cases (92 total). RESULTS: The rates of expression of Lewis y antigen and CD44 antigen were significantly greater in the drug-resistant group than that in the partially-sensitive or sensitive groups. Surgical stage, residual tumor size and expression of CD44 and Lewis y antigen in ovarian carcinoma tissues were independent risk factors for chemotherapeutic drug resistance. CONCLUSIONS: Over-expression of Lewis y and CD44 antigen are strong risk factors for chemotherapeutic drug resistance in ovarian carcinoma patients. Public Library of Science 2013-02-28 /pmc/articles/PMC3585297/ /pubmed/23468946 http://dx.doi.org/10.1371/journal.pone.0057250 Text en © 2013 HU et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Hu, Zhenhua
Gao, Jian
Zhang, Danye
Liu, Qing
Yan, Limei
Gao, Lili
Liu, Juanjuan
Liu, Dawo
Zhang, Shulan
Lin, Bei
High Expression of Lewis y Antigen and CD44 Is Correlated with Resistance to Chemotherapy in Epithelial Ovarian Cancers
title High Expression of Lewis y Antigen and CD44 Is Correlated with Resistance to Chemotherapy in Epithelial Ovarian Cancers
title_full High Expression of Lewis y Antigen and CD44 Is Correlated with Resistance to Chemotherapy in Epithelial Ovarian Cancers
title_fullStr High Expression of Lewis y Antigen and CD44 Is Correlated with Resistance to Chemotherapy in Epithelial Ovarian Cancers
title_full_unstemmed High Expression of Lewis y Antigen and CD44 Is Correlated with Resistance to Chemotherapy in Epithelial Ovarian Cancers
title_short High Expression of Lewis y Antigen and CD44 Is Correlated with Resistance to Chemotherapy in Epithelial Ovarian Cancers
title_sort high expression of lewis y antigen and cd44 is correlated with resistance to chemotherapy in epithelial ovarian cancers
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585297/
https://www.ncbi.nlm.nih.gov/pubmed/23468946
http://dx.doi.org/10.1371/journal.pone.0057250
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