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Behavior of Solvent-Exposed Hydrophobic Groove in the Anti-Apoptotic Bcl-X(L) Protein: Clues for Its Ability to Bind Diverse BH3 Ligands from MD Simulations

Bcl-X(L) is a member of Bcl-2 family of proteins involved in the regulation of intrinsic pathway of apoptosis. Its overexpression in many human cancers makes it an important target for anti-cancer drugs. Bcl-X(L) interacts with the BH3 domain of several pro-apoptotic Bcl-2 partners. This helical bun...

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Detalles Bibliográficos
Autores principales:	Lama, Dilraj, Modi, Vivek, Sankararamakrishnan, Ramasubbu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585337/ https://www.ncbi.nlm.nih.gov/pubmed/23468841 http://dx.doi.org/10.1371/journal.pone.0054397

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