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EM Structure of the Ectodomain of Integrin CD11b/CD18 and Localization of Its Ligand-Binding Site Relative to the Plasma Membrane

One-half of the integrin α-subunit Propeller domains contain and extra vWFA domain (αA domain), which mediates integrin binding to extracellular physiologic ligands via its metal-ion-dependent adhesion site (MIDAS). We used electron microscopy to determine the 3D structure of the αA-containing ectod...

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Detalles Bibliográficos
Autores principales:	Adair, Brian D., Xiong, Jian-Ping, Alonso, José Luis, Hyman, Bradley T., Arnaout, M. Amin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585415/ https://www.ncbi.nlm.nih.gov/pubmed/23469114 http://dx.doi.org/10.1371/journal.pone.0057951

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