Cargando…

NK Cells: A Double-Edged Sword in Chronic Hepatitis B Virus Infection

There is natural enrichment of NK cells in the human liver and this intrahepatic predominance underscores their potential importance in the control of infections with hepatotropic viruses such as hepatitis B virus (HBV). The contribution of innate components during chronic HBV infection has been a r...

Descripción completa

Detalles Bibliográficos
Autores principales: Maini, Mala K., Peppa, Dimitra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585438/
https://www.ncbi.nlm.nih.gov/pubmed/23459859
http://dx.doi.org/10.3389/fimmu.2013.00057
_version_ 1782261172470284288
author Maini, Mala K.
Peppa, Dimitra
author_facet Maini, Mala K.
Peppa, Dimitra
author_sort Maini, Mala K.
collection PubMed
description There is natural enrichment of NK cells in the human liver and this intrahepatic predominance underscores their potential importance in the control of infections with hepatotropic viruses such as hepatitis B virus (HBV). The contribution of innate components during chronic HBV infection has been a relatively under-investigated area. However, recent data have highlighted that NK cells are capable of exerting antiviral and immunoregulatory functions whilst also contributing to the pathogenesis of liver injury via death receptor pathways. We will present an overview of current knowledge regarding the complex biology of NK cells in the context of their antiviral versus pathogenic role in chronic hepatitis B as a clinically relevant avenue for further investigation.
format Online
Article
Text
id pubmed-3585438
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-35854382013-03-04 NK Cells: A Double-Edged Sword in Chronic Hepatitis B Virus Infection Maini, Mala K. Peppa, Dimitra Front Immunol Immunology There is natural enrichment of NK cells in the human liver and this intrahepatic predominance underscores their potential importance in the control of infections with hepatotropic viruses such as hepatitis B virus (HBV). The contribution of innate components during chronic HBV infection has been a relatively under-investigated area. However, recent data have highlighted that NK cells are capable of exerting antiviral and immunoregulatory functions whilst also contributing to the pathogenesis of liver injury via death receptor pathways. We will present an overview of current knowledge regarding the complex biology of NK cells in the context of their antiviral versus pathogenic role in chronic hepatitis B as a clinically relevant avenue for further investigation. Frontiers Media S.A. 2013-03-01 /pmc/articles/PMC3585438/ /pubmed/23459859 http://dx.doi.org/10.3389/fimmu.2013.00057 Text en Copyright © 2013 Maini and Peppa. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Immunology
Maini, Mala K.
Peppa, Dimitra
NK Cells: A Double-Edged Sword in Chronic Hepatitis B Virus Infection
title NK Cells: A Double-Edged Sword in Chronic Hepatitis B Virus Infection
title_full NK Cells: A Double-Edged Sword in Chronic Hepatitis B Virus Infection
title_fullStr NK Cells: A Double-Edged Sword in Chronic Hepatitis B Virus Infection
title_full_unstemmed NK Cells: A Double-Edged Sword in Chronic Hepatitis B Virus Infection
title_short NK Cells: A Double-Edged Sword in Chronic Hepatitis B Virus Infection
title_sort nk cells: a double-edged sword in chronic hepatitis b virus infection
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585438/
https://www.ncbi.nlm.nih.gov/pubmed/23459859
http://dx.doi.org/10.3389/fimmu.2013.00057
work_keys_str_mv AT mainimalak nkcellsadoubleedgedswordinchronichepatitisbvirusinfection
AT peppadimitra nkcellsadoubleedgedswordinchronichepatitisbvirusinfection