Cargando…
On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases
[Image: see text] Active-site directed probes are powerful in studies of enzymatic function. We report an active-site directed probe based on a warhead so far considered unreactive. By replacing the C-terminal carboxylate of ubiquitin (Ub) with an alkyne functionality, a selective reaction with the...
| Autores principales: | , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2013
|
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585465/ https://www.ncbi.nlm.nih.gov/pubmed/23387960 http://dx.doi.org/10.1021/ja309802n |