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Safety, Tolerability, and Pharmacokinetics of Etamicastat, a Novel Dopamine-β-Hydroxylase Inhibitor, in a Rising Multiple-Dose Study in Young Healthy Subjects

Background: Activation of the sympathetic nervous system is an important feature in hypertension and congestive heart failure. A strategy for directly modulating sympathetic nerve function is to reduce the biosynthesis of norepinephrine (noradrenaline) via inhibition of dopamine-β-hydroxylase (DβH)....

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Detalles Bibliográficos
Autores principales:	Nunes, Teresa, Rocha, José F., Vaz-da-Silva, Manuel, Igreja, Bruno, Wright, Lyndon C., Falcão, Amílcar, Almeida, Luis, Soares-da-Silva, Patricio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2012
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585840/ https://www.ncbi.nlm.nih.gov/pubmed/21171669 http://dx.doi.org/10.2165/11586310-000000000-00000

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