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CMV and Immunosenescence: from basics to clinics

Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates “i...

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Detalles Bibliográficos
Autores principales: Solana, Rafael, Tarazona, Raquel, Aiello, Allison E, Akbar, Arne N, Appay, Victor, Beswick, Mark, Bosch, Jos A, Campos, Carmen, Cantisán, Sara, Cicin-Sain, Luka, Derhovanessian, Evelyna, Ferrando-Martínez, Sara, Frasca, Daniela, Fulöp, Tamas, Govind, Sheila, Grubeck-Loebenstein, Beatrix, Hill, Ann, Hurme, Mikko, Kern, Florian, Larbi, Anis, López-Botet, Miguel, Maier, Andrea B, McElhaney, Janet E, Moss, Paul, Naumova, Elissaveta, Nikolich-Zugich, Janko, Pera, Alejandra, Rector, Jerrald L, Riddell, Natalie, Sanchez-Correa, Beatriz, Sansoni, Paolo, Sauce, Delphine, van Lier, Rene, Wang, George C, Wills, Mark R, Zieliński, Maciej, Pawelec, Graham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585851/
https://www.ncbi.nlm.nih.gov/pubmed/23114110
http://dx.doi.org/10.1186/1742-4933-9-23
Descripción
Sumario:Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates “immunosenescence”. This contention remains controversial and was the primary subject of the Third International Workshop on CMV & Immunosenescence which was held in Cordoba, Spain, 15-16(th) March, 2012. Discussions focused on several main themes including the effects of CMV on adaptive immunity and immunosenescence, characterization of CMV-specific T cells, impact of CMV infection and ageing on innate immunity, and finally, most important, the clinical implications of immunosenescence and CMV infection. Here we summarize the major findings of this workshop.