Comparative Cytochrome P450 In Vitro Inhibition by Atypical Antipsychotic Drugs

The goal of this study was to assess in human liver microsomes the inhibitory capacity of commonly used antipsychotics on the most prominent CYP450 drug metabolizing enzymes (CYP1A2, CYP2C9, CYP2D6, and CYP3A). Chlorpromazine was the only antipsychotic that inhibited CYP1A2 activity (IC(50) = 9.5 μM...

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Detalles Bibliográficos
Autores principales: Gervasini, Guillermo, Caballero, Maria J., Carrillo, Juan A., Benitez, Julio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586484/
https://www.ncbi.nlm.nih.gov/pubmed/23476805
http://dx.doi.org/10.1155/2013/792456

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586484/
https://www.ncbi.nlm.nih.gov/pubmed/23476805
http://dx.doi.org/10.1155/2013/792456

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