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Phytomedicines and Nutraceuticals: Alternative Therapeutics for Sickle Cell Anemia

Sickle cell anemia is a genetically inherited disease in which the “SS” individual possesses an abnormal beta globin gene. A single base substitution in the gene encoding the human β-globin subunit results in replacement of β6 glutamic acid by valine, leading to the devastating clinical manifestatio...

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Autor principal: Imaga, Ngozi Awa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586489/
https://www.ncbi.nlm.nih.gov/pubmed/23476125
http://dx.doi.org/10.1155/2013/269659
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author Imaga, Ngozi Awa
author_facet Imaga, Ngozi Awa
author_sort Imaga, Ngozi Awa
collection PubMed
description Sickle cell anemia is a genetically inherited disease in which the “SS” individual possesses an abnormal beta globin gene. A single base substitution in the gene encoding the human β-globin subunit results in replacement of β6 glutamic acid by valine, leading to the devastating clinical manifestations of sickle cell disease. This substitution causes drastic reduction in the solubility of sickle cell hemoglobin (HbS) when deoxygenated. Under these conditions, the HbS molecules polymerize to form long crystalline intracellular mass of fibers which are responsible for the deformation of the biconcave disc shaped erythrocyte into a sickle shape. First-line clinical management of sickle cell anemia include, use of hydroxyurea, folic acid, amino acids supplementation, penicillinprophylaxis, and antimalarial prophylaxis to manage the condition and blood transfusions to stabilize the patient's hemoglobin level. These are quite expensive and have attendant risk factors. However, a bright ray of hope involving research into antisickling properties of medicinal plants has been rewarding. This alternative therapy using phytomedicines has proven to not only reduce crisis but also reverse sickling (in vitro). The immense benefits of phytomedicines and nutraceuticals used in the management of sickle cell anemia are discussed in this paper.
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spelling pubmed-35864892013-03-09 Phytomedicines and Nutraceuticals: Alternative Therapeutics for Sickle Cell Anemia Imaga, Ngozi Awa ScientificWorldJournal Review Article Sickle cell anemia is a genetically inherited disease in which the “SS” individual possesses an abnormal beta globin gene. A single base substitution in the gene encoding the human β-globin subunit results in replacement of β6 glutamic acid by valine, leading to the devastating clinical manifestations of sickle cell disease. This substitution causes drastic reduction in the solubility of sickle cell hemoglobin (HbS) when deoxygenated. Under these conditions, the HbS molecules polymerize to form long crystalline intracellular mass of fibers which are responsible for the deformation of the biconcave disc shaped erythrocyte into a sickle shape. First-line clinical management of sickle cell anemia include, use of hydroxyurea, folic acid, amino acids supplementation, penicillinprophylaxis, and antimalarial prophylaxis to manage the condition and blood transfusions to stabilize the patient's hemoglobin level. These are quite expensive and have attendant risk factors. However, a bright ray of hope involving research into antisickling properties of medicinal plants has been rewarding. This alternative therapy using phytomedicines has proven to not only reduce crisis but also reverse sickling (in vitro). The immense benefits of phytomedicines and nutraceuticals used in the management of sickle cell anemia are discussed in this paper. Hindawi Publishing Corporation 2013-02-14 /pmc/articles/PMC3586489/ /pubmed/23476125 http://dx.doi.org/10.1155/2013/269659 Text en Copyright © 2013 Ngozi Awa Imaga. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Imaga, Ngozi Awa
Phytomedicines and Nutraceuticals: Alternative Therapeutics for Sickle Cell Anemia
title Phytomedicines and Nutraceuticals: Alternative Therapeutics for Sickle Cell Anemia
title_full Phytomedicines and Nutraceuticals: Alternative Therapeutics for Sickle Cell Anemia
title_fullStr Phytomedicines and Nutraceuticals: Alternative Therapeutics for Sickle Cell Anemia
title_full_unstemmed Phytomedicines and Nutraceuticals: Alternative Therapeutics for Sickle Cell Anemia
title_short Phytomedicines and Nutraceuticals: Alternative Therapeutics for Sickle Cell Anemia
title_sort phytomedicines and nutraceuticals: alternative therapeutics for sickle cell anemia
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586489/
https://www.ncbi.nlm.nih.gov/pubmed/23476125
http://dx.doi.org/10.1155/2013/269659
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