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Quantitative MRI Demonstrates Abnormality of the Fornix and Cingulum in Multiple Sclerosis
Objective. To characterize MR signal changes associated with tissue damage in the fornix and cingulum in multiple sclerosis (MS) using quantitative MRI measures and to determine associations with cognitive dysfunction. Background. The fornix and cingulum are white-matter bundles that carry informati...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586491/ https://www.ncbi.nlm.nih.gov/pubmed/23476776 http://dx.doi.org/10.1155/2013/838719 |
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author | Syc, Stephanie B. Harrison, Daniel M. Saidha, Shiv Seigo, Michaela Calabresi, Peter A. Reich, Daniel S. |
author_facet | Syc, Stephanie B. Harrison, Daniel M. Saidha, Shiv Seigo, Michaela Calabresi, Peter A. Reich, Daniel S. |
author_sort | Syc, Stephanie B. |
collection | PubMed |
description | Objective. To characterize MR signal changes associated with tissue damage in the fornix and cingulum in multiple sclerosis (MS) using quantitative MRI measures and to determine associations with cognitive dysfunction. Background. The fornix and cingulum are white-matter bundles that carry information related to cognition. While cognitive dysfunction is reported in 40–60% of MS patients, the neuroanatomical correlates of cognitive impairment remain incompletely understood. Methods. The cingulum, pillars of the fornix, and corticospinal tract were segmented by fiber tracking via diffusion tensor imaging. Average tract-specific fractional anisotropy (FA), mean diffusivity (MD), and magnetization transfer ratio (MTR) were compared in MS cases and healthy volunteers. Associations with clinical measures and neuropsychological tests were derived by multivariate linear regression. Results. Fornix FA (P = 0.004) and MTR (P = 0.005) were decreased, and fornix MD (P < 0.001) and cingulum MD (P < 0.001) increased, in MS cases (n = 101) relative to healthy volunteers (n = 16) after adjustment for age and sex. Lower fornix FA and MTR, and higher fornix MD and λ (||), were correlated with lower PASAT-3 scores, but not with slower 25FTW times. Lower PASAT-3 scores were associated with lower cingulum FA and higher MD and λ (⊥). Conclusions. Cognitive dysfunction in MS may involve damage to a widespread network of brain structures, including white-matter pathways within the limbic system. |
format | Online Article Text |
id | pubmed-3586491 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-35864912013-03-09 Quantitative MRI Demonstrates Abnormality of the Fornix and Cingulum in Multiple Sclerosis Syc, Stephanie B. Harrison, Daniel M. Saidha, Shiv Seigo, Michaela Calabresi, Peter A. Reich, Daniel S. Mult Scler Int Clinical Study Objective. To characterize MR signal changes associated with tissue damage in the fornix and cingulum in multiple sclerosis (MS) using quantitative MRI measures and to determine associations with cognitive dysfunction. Background. The fornix and cingulum are white-matter bundles that carry information related to cognition. While cognitive dysfunction is reported in 40–60% of MS patients, the neuroanatomical correlates of cognitive impairment remain incompletely understood. Methods. The cingulum, pillars of the fornix, and corticospinal tract were segmented by fiber tracking via diffusion tensor imaging. Average tract-specific fractional anisotropy (FA), mean diffusivity (MD), and magnetization transfer ratio (MTR) were compared in MS cases and healthy volunteers. Associations with clinical measures and neuropsychological tests were derived by multivariate linear regression. Results. Fornix FA (P = 0.004) and MTR (P = 0.005) were decreased, and fornix MD (P < 0.001) and cingulum MD (P < 0.001) increased, in MS cases (n = 101) relative to healthy volunteers (n = 16) after adjustment for age and sex. Lower fornix FA and MTR, and higher fornix MD and λ (||), were correlated with lower PASAT-3 scores, but not with slower 25FTW times. Lower PASAT-3 scores were associated with lower cingulum FA and higher MD and λ (⊥). Conclusions. Cognitive dysfunction in MS may involve damage to a widespread network of brain structures, including white-matter pathways within the limbic system. Hindawi Publishing Corporation 2013 2013-02-16 /pmc/articles/PMC3586491/ /pubmed/23476776 http://dx.doi.org/10.1155/2013/838719 Text en Copyright © 2013 Stephanie B. Syc et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Syc, Stephanie B. Harrison, Daniel M. Saidha, Shiv Seigo, Michaela Calabresi, Peter A. Reich, Daniel S. Quantitative MRI Demonstrates Abnormality of the Fornix and Cingulum in Multiple Sclerosis |
title | Quantitative MRI Demonstrates Abnormality of the Fornix and Cingulum in Multiple Sclerosis |
title_full | Quantitative MRI Demonstrates Abnormality of the Fornix and Cingulum in Multiple Sclerosis |
title_fullStr | Quantitative MRI Demonstrates Abnormality of the Fornix and Cingulum in Multiple Sclerosis |
title_full_unstemmed | Quantitative MRI Demonstrates Abnormality of the Fornix and Cingulum in Multiple Sclerosis |
title_short | Quantitative MRI Demonstrates Abnormality of the Fornix and Cingulum in Multiple Sclerosis |
title_sort | quantitative mri demonstrates abnormality of the fornix and cingulum in multiple sclerosis |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586491/ https://www.ncbi.nlm.nih.gov/pubmed/23476776 http://dx.doi.org/10.1155/2013/838719 |
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