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Evaluation of Adipokines: Apelin, Visfatin, and Resistin in Children with Atopic Dermatitis

Very little is known about the role of adipokines in atopic dermatitis (AD) in children. This study aimed at analyzing the serum levels of resistin, apelin, and visfatin in children with AD in relation to body weight, AD severity, and gender. Serum concentration of adipokines was measured in 27 chil...

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Autores principales: Machura, Edyta, Szczepanska, Maria, Ziora, Katarzyna, Ziora, Dariusz, Swietochowska, Elzbieta, Barc-Czarnecka, Małgorzata, Kasperska-Zajac, Alicja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586507/
https://www.ncbi.nlm.nih.gov/pubmed/23476106
http://dx.doi.org/10.1155/2013/760691
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author Machura, Edyta
Szczepanska, Maria
Ziora, Katarzyna
Ziora, Dariusz
Swietochowska, Elzbieta
Barc-Czarnecka, Małgorzata
Kasperska-Zajac, Alicja
author_facet Machura, Edyta
Szczepanska, Maria
Ziora, Katarzyna
Ziora, Dariusz
Swietochowska, Elzbieta
Barc-Czarnecka, Małgorzata
Kasperska-Zajac, Alicja
author_sort Machura, Edyta
collection PubMed
description Very little is known about the role of adipokines in atopic dermatitis (AD) in children. This study aimed at analyzing the serum levels of resistin, apelin, and visfatin in children with AD in relation to body weight, AD severity, and gender. Serum concentration of adipokines was measured in 27 children with AD and in 46 healthy subjects. Selected biochemical parameters were evaluated and skin prick test was performed. Serum levels of resistin and apelin were significantly higher, whereas serum visfatin concentration was significantly lower in children with AD versus healthy controls, although an increase in resistin levels was exclusively demonstrated in boys. In AD group, a significant increase in apelin levels in girls was documented. There was no relationship between adipokines levels and the degree of allergic sensitization. Receiver operating characteristic curve analysis demonstrated that the serum apelin cutoff value differentiating children with AD from those without was >137.8 pg/mL. Resistin and visfatin cutoff values were >3.8 ng/mL and ≤ 2.13 ng/mL, respectively. Apelin and visfatin can serve as excellent indicators to distinguish children with AD from those without disease.
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spelling pubmed-35865072013-03-09 Evaluation of Adipokines: Apelin, Visfatin, and Resistin in Children with Atopic Dermatitis Machura, Edyta Szczepanska, Maria Ziora, Katarzyna Ziora, Dariusz Swietochowska, Elzbieta Barc-Czarnecka, Małgorzata Kasperska-Zajac, Alicja Mediators Inflamm Clinical Study Very little is known about the role of adipokines in atopic dermatitis (AD) in children. This study aimed at analyzing the serum levels of resistin, apelin, and visfatin in children with AD in relation to body weight, AD severity, and gender. Serum concentration of adipokines was measured in 27 children with AD and in 46 healthy subjects. Selected biochemical parameters were evaluated and skin prick test was performed. Serum levels of resistin and apelin were significantly higher, whereas serum visfatin concentration was significantly lower in children with AD versus healthy controls, although an increase in resistin levels was exclusively demonstrated in boys. In AD group, a significant increase in apelin levels in girls was documented. There was no relationship between adipokines levels and the degree of allergic sensitization. Receiver operating characteristic curve analysis demonstrated that the serum apelin cutoff value differentiating children with AD from those without was >137.8 pg/mL. Resistin and visfatin cutoff values were >3.8 ng/mL and ≤ 2.13 ng/mL, respectively. Apelin and visfatin can serve as excellent indicators to distinguish children with AD from those without disease. Hindawi Publishing Corporation 2013 2013-02-14 /pmc/articles/PMC3586507/ /pubmed/23476106 http://dx.doi.org/10.1155/2013/760691 Text en Copyright © 2013 Edyta Machura et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Machura, Edyta
Szczepanska, Maria
Ziora, Katarzyna
Ziora, Dariusz
Swietochowska, Elzbieta
Barc-Czarnecka, Małgorzata
Kasperska-Zajac, Alicja
Evaluation of Adipokines: Apelin, Visfatin, and Resistin in Children with Atopic Dermatitis
title Evaluation of Adipokines: Apelin, Visfatin, and Resistin in Children with Atopic Dermatitis
title_full Evaluation of Adipokines: Apelin, Visfatin, and Resistin in Children with Atopic Dermatitis
title_fullStr Evaluation of Adipokines: Apelin, Visfatin, and Resistin in Children with Atopic Dermatitis
title_full_unstemmed Evaluation of Adipokines: Apelin, Visfatin, and Resistin in Children with Atopic Dermatitis
title_short Evaluation of Adipokines: Apelin, Visfatin, and Resistin in Children with Atopic Dermatitis
title_sort evaluation of adipokines: apelin, visfatin, and resistin in children with atopic dermatitis
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586507/
https://www.ncbi.nlm.nih.gov/pubmed/23476106
http://dx.doi.org/10.1155/2013/760691
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