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Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity

BACKGROUND: Filaggrin, coded by FLG, is the main source of several major components of natural moisturizing factor (NMF) in the stratum corneum (SC), including pyrrolidone carboxylic acid (PCA) and urocanic acid (UCA). Loss-offunction mutations in FLG lead to reduced levels of filaggrin degradation...

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Detalles Bibliográficos
Autores principales:	Kezic, S, O’Regan, G M, Yau, N, Sandilands, A, Chen, H, Campbell, L E, Kroboth, K, Watson, R, Rowland, M, Irwin McLean, W H, Irvine, A D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2011
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586662/ https://www.ncbi.nlm.nih.gov/pubmed/21261659 http://dx.doi.org/10.1111/j.1398-9995.2010.02540.x

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