Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics

Genetically encoded calcium indicators (GECIs) are powerful tools for systems neuroscience. Here we describe red, single-wavelength GECIs, “RCaMPs,” engineered from circular permutation of the thermostable red fluorescent protein mRuby. High-resolution crystal structures of mRuby, the red sensor RCa...

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Detalles Bibliográficos
Autores principales: Akerboom, Jasper, Carreras Calderón, Nicole, Tian, Lin, Wabnig, Sebastian, Prigge, Matthias, Tolö, Johan, Gordus, Andrew, Orger, Michael B., Severi, Kristen E., Macklin, John J., Patel, Ronak, Pulver, Stefan R., Wardill, Trevor J., Fischer, Elisabeth, Schüler, Christina, Chen, Tsai-Wen, Sarkisyan, Karen S., Marvin, Jonathan S., Bargmann, Cornelia I., Kim, Douglas S., Kügler, Sebastian, Lagnado, Leon, Hegemann, Peter, Gottschalk, Alexander, Schreiter, Eric R., Looger, Loren L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586699/
https://www.ncbi.nlm.nih.gov/pubmed/23459413
http://dx.doi.org/10.3389/fnmol.2013.00002

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